ReviewPain research and treatment2014
Perineural dexamethasone to improve postoperative analgesia with peripheral nerve blocks: a meta-analysis of randomized controlled trials.
Review in Pain research and treatment, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02749162 (Perineural Dexamethasone Administered in Femural Nerve Block After Anterior Cruciate Ligament Reconstruction), which is not on this map. Cited by 25 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Perineural Dexamethasone Administered in Femural Nerve Block After Anterior Cruciate Ligament Reconstruction
Who cites it
25 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Perineural dexamethasone added to peripheral nerve block in knee surgery: a systematic review with meta-analysis.Anaesthesiology intensive therapy · 2025Pooled it
- The effect of ultrasound-guided erector spinae plane block on postsurgical pain: a meta-analysis of randomized controlled trials.BMC anesthesiology · 2020Pooled it
- Dexamethasone as an adjuvant to peripheral nerve block.The Cochrane database of systematic reviews · 2017Pooled it
- Perineural dexamethasone as an adjuvant to erector spinae plane block for acute and chronic pain after cardiac surgery.Scientific reports · 2026Trial
- A Comparative Analysis of Pain Control Methods after Ankle Fracture Surgery with a Peripheral Nerve Block: A Single-Center Randomized Controlled Prospective Study.Medicina (Kaunas, Lithuania) · 2023Trial
- Safety and Duration of Low-Dose Adjuvant Dexamethasone in Regional Anesthesia for Upper Extremity Surgery: A Prospective, Randomized, Controlled Blinded Study.Hand (New York, N.Y.) · 2022Trial
- The Combination of IV and Perineural Dexamethasone Prolongs the Analgesic Duration of Intercostal Nerve Blocks Compared with IV Dexamethasone Alone.Pain medicine (Malden, Mass.) · 2017Trial
- Particulate-steroid betamethasone added to ropivacaine in interscalene brachial plexus block for arthroscopic rotator cuff repair improves postoperative analgesia.BMC anesthesiology · 2016Trial
- Trial
- [Perineural dexamethasone in ultrasound-guided interscalene brachial plexus block with levobupivacaine for shoulder arthroscopic surgery in the outpatient setting: randomized controlled trial].Brazilian journal of anesthesiology (Elsevier)Trial
- Article
- Enhanced rehabilitation after surgery: principles in the treatment of emergency complicated colorectal cancers - a narrative review.Journal of medicine and life · 2025Review
- Article
- Surgical treatment and outcomes of pectus arcuatum.JTCVS techniques · 2024Article
- The Use of Peripheral Nerve Block and Intra-articular Steroid Injection for Pain Management in an Adolescent with Hutchinson-Gilford Progeria Syndrome: A Case Report.Acta medica Philippina · 2024Article
- Ultrasound-guided genicular nerve block a new treatment in rheumatology for knee osteoarthritis pain.Rheumatology international · 2022Article
- Adjuvant Drugs for Peripheral Nerve Blocks: The Role of Alpha-2 Agonists, Dexamethasone, Midazolam, and Non-steroidal Anti-inflammatory Drugs.Anesthesiology and pain medicine · 2021Review
- Article
- Effect of dexamethasone as an adjuvant to ropivacaine on duration and quality of analgesia in ultrasound-guided transversus abdominis plane block in patients undergoing lower segment cesarean section - A prospective, randomised, single-blinded study.Indian journal of anaesthesia · 2019Article
- Designing the ideal perioperative pain management plan starts with multimodal analgesia.Korean journal of anesthesiology · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background. The overall effect of perineural dexamethasone on postoperative analgesia outcomes has yet to be quantified. The main objective of this quantitative review was to evaluate the effect of perineural dexamethasone as a nerve block adjunct on postoperative analgesia outcomes. Methods. A systematic search was performed to identify randomized controlled trials that evaluated the effects of perineural dexamethasone as a block adjunct on postoperative pain outcomes in patients receiving regional anesthesia. Meta-analysis was performed using a random-effect model. Results. Nine randomized trials with 760 subjects were included. The weighted mean difference (99% CI) of the combined effects favored perineural dexamethasone over control for analgesia duration, 473 (264 to 682) minutes, and motor block duration, 500 (154 to 846) minutes. Postoperative opioid consumption was also reduced in the perineural dexamethasone group compared to control, -8.5 (-12.3 to -4.6) mg of IV morphine equivalents. No significant neurological symptoms could have been attributed to the use of perineural dexamethasone. Conclusions. Perineural dexamethasone improves postoperative pain outcomes when given as an adjunct to brachial plexus blocks. There were no reports of persistent nerve injury attributed to perineural administration of the drug.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.