ArticleAIDS research and treatment2014
Establishment of Normal Reference Intervals for CD3(+), CD4(+), CD8(+), and CD4(+) to CD8(+) Ratio of T Lymphocytes in HIV Negative Adults from University of Gondar Hospital, North West Ethiopia.
Article in AIDS research and treatment, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 16 citations in OpenAlex.
- Establishing population-based reference intervals for hematological parameters among apparently healthy adults in Northwest Ethiopia, 2023.Scientific reports · 2026Article
- Reference values of lymphocyte subsets from healthy Polish adults.Central-European journal of immunology · 2024Article
- Reference Intervals for Absolute and Percentage CD4International journal of general medicine · 2022Article
- Chronic Immune Activation and CD4Frontiers in immunology · 2021Review
- Establishment of reference range of CD4 T-lymphocyte in healthy Nepalese adults.BMC research notes · 2020Article
- Prediction of CD4 T-Lymphocyte Count Using WHO Clinical Staging among ART-Naïve HIV-Infected Adolescents and Adults in Northern Ethiopia: A Retrospective Study.AIDS research and treatment · 2020Article
- Assessment of the AQUIOS flow cytometer - An automated sample preparation system for CD4 lymphocyte PanLeucogating enumeration.African journal of laboratory medicine · 2019Article
- Article
- Predictors of CD4 count over time among HIV patients initiated ART in Felege Hiwot Referral Hospital, northwest Ethiopia: multilevel analysis.BMC research notes · 2016Article
- Phenotypic and functional characteristics of IL-21-expressing CD8(+) T cells in human nasal polyps.Scientific reports · 2016Article
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background. Reference values for the CD3(+), CD4(+), CD8(+), and CD4(+) to CD8(+) ratio T lymphocyte subsets are adopted from textbooks. But for appropriate diagnosis, treatment, and follow-up of patients, correct interpretations of the laboratory results from normal reference interval are mandatory. This study was, therefore, planned to establish normal reference interval for T lymphocytes subset count and CD4(+) to CD8(+) ratio. Methods. A cross-sectional study was conducted on apparently healthy adult individuals who visited voluntary counseling and HIV testing clinic Gondar University Hospital from April to May, 2013. Whole blood was analyzed using fluorescence-activated cell sorting (BD FACS, San Jose, CA) machine to enumerate the T-cell subpopulations. Results. Out of the total 320 study participants, 161 (50.3%) were men and 159 (49.7%) were women. The normal reference intervals were (655-2,823 cells/μL), (321-1,389 cells/μL), and (220-1,664 cells/μL) for CD3(+), CD4(+), and CD8(+) T lymphocyte subsets, respectively, and CD4(+) to CD8(+) ratio was 0.5-2.5. Conclusion. The overall CD3(+) T lymphocytes reference interval in the current study was wide; low CD4(+) T lymphocytes, CD4 to CD8 ratio, and high CD8(+) T lymphocytes values were observed.
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