Evidence map›Paper›PMID 25485141›Full record

ArticleMedical sciences (Basel, Switzerland)2013

Response of Differentiated Human Airway Epithelia to Alcohol Exposure and

Sammeta V Raju, Richard G Painter, Gregory J Bagby, Steve Nelson, Guoshun Wang

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Medical sciences (Basel, Switzerland), 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.3field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Sammeta V RajuComprehensive Alcohol Research Center, Department of Genetics, Louisiana State University Health Sciences Center, New Orleans, LA 70112, USA.
Richard G PainterComprehensive Alcohol Research Center, Department of Microbiology, Louisiana State University Health Sciences Center, New Orleans, LA 70112, USA.
Gregory J BagbyComprehensive Alcohol Research Center, Department of Physiology, Louisiana State University Health Sciences Center, New Orleans, LA 70112, USA.
Steve NelsonComprehensive Alcohol Research Center, Department of Medicine, Louisiana State University Health Sciences Center, New Orleans, LA 70112, USA.
Guoshun WangComprehensive Alcohol Research Center, Department of Genetics, Louisiana State University Health Sciences Center, New Orleans, LA 70112, USA ; Comprehensive Alcohol Research Center, Department of Microbiology, Louisiana State University Health Sciences Center, New Orleans, LA 70112, USA ; Comprehensive Alcohol Research Center, Department of Medicine, Louisiana State University Health Sciences Center, New Orleans, LA 70112, USA.
Louisiana State University Health Sciences Center New Orleans · US

Funding

PILOT--IMPACT OF ALCOHOLISM ON AIDS ASOCIATED MUSCLE WASTINGP50AA009803 · NIAAA · LOUISIANA STATE UNIV HSC NEW ORLEANS · PI NELSON, STEVE · 1994 to 2003
$7.2M
Alcohol Effects on Gene and Cytokine Expression of Human Airway EpitheliaR21AA016118 · NIAAA · LSU HEALTH SCIENCES CENTER · PI WANG, GUOSHUN · 2007 to 2009
$399k
NIAAA NIH HHS P50 AA009803NIAAA NIH HHS R21 AA016118
6 · The paper itself

Abstract

Alcohol abuse has been associated with increased susceptibility to pulmonary infection. It is not fully defined how alcohol contributes to the host defense compromise. Here primary human airway epithelial cells were cultured at an air-liquid interface to form a differentiated and polarized epithelium. This unique culture model allowed us to closely mimic lung infection in the context of alcohol abuse by basolateral alcohol exposure and apical live bacterial challenge. Application of clinically relevant concentrations of alcohol for 24 hours did not significantly alter epithelial integrity or barrier function. When apically challenged with viable

Indexed as

Adenosine receptorAir-liquid interface cultureAlcoholCytokinesEpithelial barrier functionHuman airway epitheliaKlebsiella pneumoniae bacteria

Identifiers

PMID25485141
PMCPMC4255281
OpenAlexW2073786060

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.