Evidence map›Paper›PMID 25485115›Full record

ArticleJournal of materials chemistry. B2014

Dextran coated bismuth-iron oxide nanohybrid contrast agents for computed tomography and magnetic resonance imaging.

Pratap C Naha, Ajlan Al Zaki, Elizabeth Hecht, Michael Chorny, Peter Chhour, Eric Blankemeyer, Douglas M Yates, Walter R T Witschey, Harold I Litt, Andrew Tsourkas and 1 more

Abstract read
In one paragraph

Article in Journal of materials chemistry. B, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.

0numbers the graph read from it
0cells of the map it votes in
39citing papers in PubMed
5.0field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

39 citing papers in PubMed, 126 citations in OpenAlex.

  1. Review
  2. Article
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  8. Review
  9. Nanomaterial-based contrast agents.Nature reviews. Methods primers · 2023
    Article
  10. Article
  11. Review
  12. Facile Fabrication of BiFNanoscale research letters · 2021
    Article
  13. Imaging Constructs: The Rise of Iron Oxide Nanoparticles.Molecules (Basel, Switzerland) · 2021
    Review
  14. Review
  15. Review
  16. Article
  17. Review
  18. Nanoparticle contrast agents for X-ray imaging applications.Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology · 2020
    Review
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

Pratap C NahaDepartment of Radiology, University of Pennsylvania, Philadelphia, PA, USA.
Ajlan Al ZakiDepartment of Bioengineering, University of Pennsylvania, Philadelphia, PA, USA.
Elizabeth HechtDepartment of Radiology, University of Pennsylvania, Philadelphia, PA, USA.
Michael ChornyDepartment of Pediatrics, The Children's Hospital of Philadelphia, Philadelphia, PA, USA.
Peter ChhourDepartment of Radiology, University of Pennsylvania, Philadelphia, PA, USA ; Department of Bioengineering, University of Pennsylvania, Philadelphia, PA, USA.
Eric BlankemeyerSmall Animal Imaging Facility, University of Pennsylvania, PA, USA.
Douglas M YatesNanoscale Characterization Facility, University of Pennsylvania, PA, USA.
Walter R T WitscheyDepartment of Radiology, University of Pennsylvania, Philadelphia, PA, USA ; Department of Bioengineering, University of Pennsylvania, Philadelphia, PA, USA ; Division of Cardiovascular Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Harold I LittDepartment of Radiology, University of Pennsylvania, Philadelphia, PA, USA ; Division of Cardiovascular Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Andrew TsourkasDepartment of Bioengineering, University of Pennsylvania, Philadelphia, PA, USA.
David P CormodeDepartment of Radiology, University of Pennsylvania, Philadelphia, PA, USA ; Department of Bioengineering, University of Pennsylvania, Philadelphia, PA, USA ; Division of Cardiovascular Medicine, University of Pennsylvania, Philadelphia, PA, USA.
California University of Pennsylvania · USPhiladelphia University · USUniversity of Pennsylvania · US

Funding

Institutional Clinical and Translational Science AwardUL1TR000003 · NCATS · UNIVERSITY OF PENNSYLVANIA · PI FITZGERALD, GARRET A · 2012 to 2015
$38.9M
Translational Research Support CoreP30ES013508 · NIEHS · UNIVERSITY OF PENNSYLVANIA · PI Rebecca A Simmons · 2006 to 2026
$35.3M
Nuclear Magnetic Tirho Relaxation in Acute and Chronic Myocardial InfarctionsR00HL108157 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI WITSCHEY, WALTER R.T. · 2014 to 2016
$747k
Theranostic Nanoparticles to enhance morpholino delivery to the liver for suppresR00EB012165 · NIBIB · UNIVERSITY OF PENNSYLVANIA · PI CORMODE, DAVID PETER · 2012 to 2014
$706k
NCATS NIH HHS UL1 TR000003NHLBI NIH HHS R00 HL108157NIBIB NIH HHS R00 EB012165NIEHS NIH HHS P30 ES013508
6 · The paper itself

Abstract

Bismuth nanoparticles have been proposed as a novel CT contrast agent, however few syntheses of biocompatible bismuth nanoparticles have been achieved. We herein report the synthesis of composite bismuth-iron oxide nanoparticles (BION) that are based on a clinically approved, dextran-coated iron oxide formulation; the particles have the advantage of acting as contrast agents for both CT and MRI. BION were synthesized and characterized using various analytical methods. BION CT phantom images revealed that the X-ray attenuation of the different formulations was dependent upon the amount of bismuth present in the nanoparticle, while T

Indexed as

Bismuthcomputed tomographycontrast agentiron oxidemagnetic resonance imagingnanoparticle

Identifiers

PMID25485115
PMCPMC4251562
OpenAlexW2058454295

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.