Evidence map›Paper›PMID 25485114›Full record

ArticleJournal of materials chemistry. B2014

Highly compacted pH-responsive DNA nanoparticles mediate transgene silencing in experimental glioma.

Anthony J Kim, Graeme F Woodworth, Nicholas J Boylan, Jung Soo Suk, Justin Hanes

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of materials chemistry. B, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.4field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 9 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
  4. Article
  5. Review
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 4 institutions in 2 countries.

Anthony J KimDepartment of Neurosurgery, University of Maryland School of Medicine, 22 South Green Street, Baltimore, MD 21201 (USA) ; Department of Pharmaceutical Sciences, University of Maryland School of Pharmacy, Baltimore, MD 21201 (USA) ; Center for Nanomedicine, Johns Hopkins University School of Medicine, 400 North Broadway Street, Baltimore, MD 21231 (USA).
Graeme F WoodworthDepartment of Neurosurgery, University of Maryland School of Medicine, 22 South Green Street, Baltimore, MD 21201 (USA) ; Center for Nanomedicine, Johns Hopkins University School of Medicine, 400 North Broadway Street, Baltimore, MD 21231 (USA).
Nicholas J BoylanCenter for Nanomedicine, Johns Hopkins University School of Medicine, 400 North Broadway Street, Baltimore, MD 21231 (USA).
Jung Soo SukCenter for Nanomedicine, Johns Hopkins University School of Medicine, 400 North Broadway Street, Baltimore, MD 21231 (USA).
Justin HanesCenter for Nanomedicine, Johns Hopkins University School of Medicine, 400 North Broadway Street, Baltimore, MD 21231 (USA) ; Department of Ophthalmology, Biomedical Engineering, Chemical & Biomolecular Engineering, Neurosurgery, and Oncology, Johns Hopkins University School of Medicine, 400 North Broadway Street, Baltimore, MD 21231 (USA) ; Center for Cancer Nanotechnology Excellence, Institute for NanoBioTechnology, Johns Hopkins University, Baltimore, Maryland, 21231 (USA).
Johns Hopkins University · USJohns Hopkins Medicine · USNanomed (Brazil) · BRUniversity of Baltimore · US

Funding

Transitioning Early Career Neurosurgeons to Scientific IndependenceK12NS080223 · NINDS · MASSACHUSETTS GENERAL HOSPITAL · PI ESKANDAR, EMAD N · 2012 to 2022
$9.2M
T32: Predoctoral and Postdoctoral Training Program in Nanotechnology for Cancer ResearchT32CA153952 · NCI · JOHNS HOPKINS UNIVERSITY · PI Denis Wirtz · 2015 to 2026
$3.5M
Brain Tumor-Penetrating Nanoparticle Delivery with MR-Guided Focused UltrasoundR01CA164789 · NCI · UNIVERSITY OF VIRGINIA · PI HANES, JUSTIN S., PRICE, RICHARD J. · 2012 to 2016
$3.1M
T-32 NIH Postdoctoral Training Program in Nanotechnology for Cancer Medicine NTCMT32CA130840 · NCI · JOHNS HOPKINS UNIVERSITY · PI WIRTZ, DENIS · 2008 to 2012
$1.2M
Brain-Penetrating Nanoparticle Therapeutics for Invasive Brain CancerK08NS090430 · NINDS · UNIVERSITY OF MARYLAND BALTIMORE · PI WOODWORTH, GRAEME F · 2014 to 2018
$748k
Fn14-targeted Therapeutics for Invasive Brain CancerK25EB018370 · NIBIB · UNIVERSITY OF MARYLAND BALTIMORE · PI KIM, ANTHONY J. · 2014 to 2016
$390k
Design of Non-viral Gene Carriers that Overcome Extra- and Intracellular BarriersF32HL103137 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI KIM, ANTHONY J. · 2011 to 2012
$102k
NCI NIH HHS R01 CA164789NCI NIH HHS T32 CA130840NCI NIH HHS T32 CA153952NHLBI NIH HHS F32 HL103137NIBIB NIH HHS K25 EB018370NINDS NIH HHS K08 NS090430NINDS NIH HHS K12 NS080223
6 · The paper itself

Abstract

Complex genetic mutations are common in brain cancer, making gene therapy an attractive approach to repair or modulate altered genes and cellular pathways. Non-viral gene vectors can offer DNA delivery without the risk of immunogenicity and/or insertional mutagenesis that are common with viral vectors. We developed pH-responsive DNA nanoparticles, CH

Indexed as

Brain CancerDNA NanoparticlesGBMGene TherapyshRNA

Identifiers

PMID25485114
PMCPMC4254827
OpenAlexW2058628910

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.