ArticleInterface focus2014
A kinetic mechanism for cell sorting based on local variations in cell motility.
Article in Interface focus, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed.
- Spatial self-organization of cancer stem cell niches revealed by live single-cell imaging.Stem cell research & therapy · 2025Article
- Topological data analysis of spatial patterning in heterogeneous cell populations: clustering and sorting with varying cell-cell adhesion.NPJ systems biology and applications · 2023Article
- Is cell segregation like oil and water: Asymptotic versus transitory regime.PLoS computational biology · 2022Article
- Large-scale simulations of biological cell sorting driven by differential adhesion follow diffusion-limited domain coalescence regime.PLoS computational biology · 2021Article
- Neuron and astrocyte aggregation and sorting in three-dimensional neuronal constructs.Communications biology · 2021Article
- PhysiBoSS: a multi-scale agent-based modelling framework integrating physical dimension and cell signalling.Bioinformatics (Oxford, England) · 2019Article
- Functional Epithelium Remodeling in Response to Applied Stress underApplied bionics and biomechanics · 2019Article
- Sorting Things Out: Cell Sorting during Hydra Regeneration.Biophysical journal · 2017Article
- Physical Mechanisms Driving Cell Sorting in Hydra.Biophysical journal · 2017Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
Our current understanding of cell sorting relies on physical difference, either in the interfacial properties or motile force, between cell types. But is such asymmetry a prerequisite for cell sorting? We test this using a minimal model in which the two cell populations are identical with respect to their physical properties and differences in motility arise solely from how cells interact with their surroundings. The model resembles the Schelling model used in social sciences to study segregation phenomena at the scale of societies. Our results demonstrate that segregation can emerge solely from cell motility being a dynamic property that changes in response to the local environment of the cell, but that additional mechanisms are necessary to reproduce the envelopment behaviour observed in vitro. The time course of segregation follows a power law, in agreement with the scaling reported from experiment and in other models of motility-driven segregation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.