ArticleInterface focus2014
A minimal model for metabolism-dependent chemotaxis in Rhodobacter sphaeroides (†).
Article in Interface focus, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
2 citing papers in PubMed.
- Enhancing the 1-Aminocyclopropane-1-Carboxylate Metabolic Rate ofMicroorganisms · 2020Article
- Ultrasensitive Negative Feedback Control: A Natural Approach for the Design of Synthetic Controllers.PloS one · 2016Article
Corrections and comments
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Authors and funding
2 authors.
Funding
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Abstract
Chemotaxis is vital cellular movement in response to environmental chemicals. Unlike the canonical chemotactic pathway in Escherichia coli, Rhodobacter sphaeroides has both transmembrane and cytoplasmic sensory clusters, with the latter possibly interacting with essential components in the electron transport system. However, the effect of the cytoplasmic sensor and the mechanism of signal integration from both sensory clusters remain unclear. Based on a minimal model of the chemotaxis pathway in this species, we show that signal integration at the motor level produces realistic chemotactic behaviour in line with experimental observations. Our model also suggests that the core pathway of R. sphaeroides, at least its ancestor, may represent a metabolism-dependent selective stopping strategy, which alone can steer cells to favourable environments. Our results not only clarify the potential roles of the two sensory clusters but also put in question the current definitions of attractants and repellents.
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Registered trials
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