ArticleChemosensory perception2012
Orosensory and Homeostatic Functions of the Insular Taste Cortex.
Article in Chemosensory perception, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 2 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
26 citing papers in PubMed, 2 syntheses or guidelines pooled it, 62 citations in OpenAlex.
- A systematic review of resting-state functional connectivity in obesity: Refining current neurobiological frameworks and methodological considerations moving forward.Reviews in endocrine & metabolic disorders · 2022Pooled it
- Mapping brain activity of gut-brain signaling to appetite and satiety in healthy adults: A systematic review and functional neuroimaging meta-analysis.Neuroscience and biobehavioral reviews · 2022Pooled it
- Obesity is associated with altered mid-insula functional connectivity to limbic regions underlying appetitive responses to foods.Journal of psychopharmacology (Oxford, England) · 2017Trial
- Characterization and postprandial regulation of the nutrient-sensing machinery in the oral floor mucosa of 10-week-old mule ducks.Poultry science · 2026Article
- Differential brain response to a highly palatable drink in chronic low back pain patients.Journal of neurophysiology · 2026Article
- Effect of Phenolic Compounds and Terpenes on the Flavour and Functionality of Plant-Based Foods.Nutrients · 2025Review
- An interoceptive model of energy allostasis linking metabolic and mental health.Science advances · 2025Review
- Tastes and retronasal odours evoke a shared flavour-specific neural code in the human insula.Nature communications · 2025Article
- Separating Subjective from Objective Food Value in the Human Insula: An Exploratory Study Using Intracranial EEG.Brain sciences · 2025Article
- An intra-oral flavor detection task in freely moving mice.iScience · 2024Article
- Brain activity associated with taste stimulation: A mechanism for neuroplastic change?Brain and behavior · 2023Article
- A common neural code for representing imagined and inferred tastes.Progress in neurobiology · 2023Article
- The orbitofrontal cortex, food reward, body weight and obesity.Social cognitive and affective neuroscience · 2023Article
- The Impact of Restrictive and Non-restrictive Dietary Weight Loss Interventions on Neurobehavioral Factors Related to Body Weight Control: the Gaps and Challenges.Current obesity reports · 2021Review
- Against gustotopic representation in the human brain: There is no Cartesian Restaurant.Current opinion in physiology · 2021Article
- The Phantom Satiation Hypothesis of Bariatric Surgery.Frontiers in neuroscience · 2021Article
- Regulating food craving: From mechanisms to interventions.Physiology & behavior · 2020Review
- Insular resting state functional connectivity is associated with gut microbiota diversity.The European journal of neuroscience · 2019Article
- Alterations in the gustatory papillae after anterior bite plate insertion in growing rats.Journal of orthodontic science · 2019Article
- Neurons with diverse phenotypes project from the caudal to the rostral nucleus of the solitary tract.The Journal of comparative neurology · 2018Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
The gustatory aspect of the insular cortex is part of the brain circuit that controls ingestive behaviors based on chemosensory inputs. However, the sensory properties of foods are not restricted to taste and should also include salient features such as odor, texture, temperature, and appearance. Therefore, it is reasonable to hypothesize that specialized circuits within the central taste pathways must be involved in representing several other oral sensory modalities in addition to taste. In this review, we evaluate current evidence indicating that the insular gustatory cortex functions as an integrative circuit, with taste-responsive regions also showing heightened sensitivity to olfactory, somatosensory, and even visual stimulation. We also review evidence for modulation of taste-responsive insular areas by changes in physiological state, with taste-elicited neuronal responses varying according to the nutritional state of the organism. We then examine experimental support for a functional map within the insular cortex that might reflect the various sensory and homeostatic roles associated with this region. Finally, we evaluate the potential role of the taste insular cortex in weight-gain susceptibility. Taken together, the current experimental evidence favors the view that the insular gustatory cortex functions as an orosensory integrative system that not only enables the formation of complex flavor representations but also mediates their modulation by the internal state of the body, playing therefore a central role in food intake regulation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.