ArticleCellular and molecular bioengineering2014
Characterization of mechanical and regenerative properties of human, adipose stromal cells.
Article in Cellular and molecular bioengineering, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 2 of them syntheses that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
13 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Efficacy and Safety of Stromal Vascular Fraction in the Treatment of Tear Trough Deformity: A Systematic Review and Meta-Analysis.Aesthetic plastic surgery · 2025Pooled it
- Cell-Assisted Lipotransfer: A Systematic Review of Its Efficacy.Aesthetic plastic surgery · 2016Pooled it
- Influence of Donor Age, Donor Body Mass Index, and Harvesting Site on Cell Preparations from Human Adipose Tissue.International journal of molecular sciences · 2026Article
- Improving Fat Transplantation Survival and Vascularization with Adenovirus E4+ Endothelial Cell-Assisted Lipotransfer.Cells, tissues, organs · 2023Article
- Discovery of surface biomarkers for cell mechanophenotype via an intracellular protein-based enrichment strategy.Cellular and molecular life sciences : CMLS · 2022Article
- Elucidating nanoscale mechanical properties of diabetic human adipose tissue using atomic force microscopy.Scientific reports · 2020Article
- Considerations for high-yield, high-throughput cell enrichment: fluorescence versus magnetic sorting.Scientific reports · 2019Article
- Regenerative Potential and Inflammation-Induced Secretion Profile of Human Adipose-Derived Stromal Vascular Cells Are Influenced by Donor Variability and Prior Breast Cancer Diagnosis.Stem cell reviews and reports · 2018Article
- Mechanical properties of stem cells from different sources during vascular smooth muscle cell differentiation.Molecular & cellular biomechanics : MCB · 2017Article
- Fabricating polyacrylamide microbeads by inverse emulsification to mimic the size and elasticity of living cells.Biomaterials science · 2016Article
- High-Throughput Assessment of Cellular Mechanical Properties.Annual review of biomedical engineering · 2015Review
- Gene expression-based enrichment of live cells from adipose tissue produces subpopulations with improved osteogenic potential.Stem cell research & therapy · 2014Article
- Impact of aging on the regenerative properties of bone marrow-, muscle-, and adipose-derived mesenchymal stem/stromal cells.PloS one · 2014Article
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
The stromal vascular fraction (SVF) of human adipose tissue is a heterogeneous population, with component cell types that may or may not contribute to its regenerative potential. Recent findings indicate that single-cell mechanical biomarkers are characteristic of cell type and can be used comparably to gene and protein expressions to identify cell populations. In this study, we characterized mechanical properties and differentiation potential of cell types present in the SVF. Fluorescence-activated cell sorting was used to isolate four distinct populations based on surface markers: endothelial cells (EC), adipose-derived stem cells (ASCs), pre-adipocytes, and smooth muscle cells (SMC). Atomic force microscopy was used to mechanically characterize sorted cell populations and unsorted SVF. Differentiation capabilities of sorted and unsorted populations were evaluated by quantifying lipid production and calcified matrix deposition. Cells populating the SVF exhibited a range of mechanical properties, with ECs, ASCs, pre-adipocytes, and unsorted SVF cells being significantly more compliant than SMCs. Lineage-specific metabolite production was most robust in SVF cells, followed by ASCs, with the other cell types showing little or no potential, suggesting the unsorted populations may benefit from a paracrine response that is lacking once the cells are sorted into more uniform cell populations.
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Registered trials
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