ArticleNeuropsychiatric disease and treatment2014
Altered intrinsic regional brain spontaneous activity and subjective sleep quality in patients with chronic primary insomnia: a resting-state fMRI study.
Article in Neuropsychiatric disease and treatment, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 87 papers, 8 of them syntheses that pooled it.
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Who cites it
87 citing papers in PubMed, 8 syntheses or guidelines pooled it, 120 citations in OpenAlex.
- Structural rather than functional brain alterations that characterize the differences between major depressive disorder and primary insomnia: a comparative meta-analysis.BMC medicine · 2025Pooled it
- Comparison of resting-state brain activity between insomnia and generalized anxiety disorder: A coordinate-based meta-analysis.Brain imaging and behavior · 2025Pooled it
- Distinct functional brain abnormalities in insomnia disorder and obstructive sleep apnea.European archives of psychiatry and clinical neuroscience · 2023Pooled it
- Effect-size seed-based d mapping of resting-state fMRI for persistent insomnia disorder.Sleep & breathing = Schlaf & Atmung · 2020Pooled it
- Pooled it
- Genome-wide analysis of insomnia in 1,331,010 individuals identifies new risk loci and functional pathways.Nature genetics · 2019Pooled it
- A lack of consistent brain alterations in insomnia disorder: An activation likelihood estimation meta-analysis.Sleep medicine reviews · 2018Pooled it
- Functional reorganization in obstructive sleep apnoea and insomnia: A systematic review of the resting-state fMRI.Neuroscience and biobehavioral reviews · 2017Pooled it
- Trial
- Article
- Assessment of Intravoxel Incoherent Motion Diffusion-Weighted Imaging in Insomnia.Brain and behavior · 2025Article
- Multimodal integration of homotopic connectivity and transcriptomic signatures in major depressive disorder with sleep disorder comorbidity.BMC psychiatry · 2025Article
- Cortical excitability and brain function in patients with insomnia: a pilot transcranial magnetic stimulation and functional near-infrared spectroscopy study.Frontiers in neuroscience · 2025Article
- Functional connectivity of paired default mode network subregions in patients with eye trauma.International journal of ophthalmology · 2024Article
- Insomnia-related brain functional correlates in first-episode drug-naïve major depressive disorder revealed by resting-state fMRI.Frontiers in neuroscience · 2024Article
- Enhanced functional connectome of cerebellum in chronic insomnia patients.Brain and behavior · 2023Article
- The relationship between processing speed and remodeling spatial patterns of intrinsic brain activity in the elderly with different sleep duration.Frontiers in neuroscience · 2023Article
- Psychological resilience mediates the association of the middle frontal gyrus functional connectivity with sleep quality.Brain imaging and behavior · 2022Article
- Comparisons of resting-state brain activity between insomnia and schizophrenia: a coordinate-based meta-analysis.Schizophrenia (Heidelberg, Germany) · 2022Review
- Spindle-related brain activation in patients with insomnia disorder: An EEG-fMRI study.Brain imaging and behavior · 2022Article
27 more citing papers are in PubMed but not listed here.
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
STUDY
objectiveTo prospectively explore the underlying regional homogeneity (ReHo) brain-activity deficit in patients with chronic primary insomnia (PCPIs) and its relationship with clinical features.
designThe ReHo method and Statistical Parametric Mapping 8 software were used to evaluate whether resting-state localized brain activity was modulated between PCPIs and good sleepers (GSs), and correlation analysis between altered regional brain areas and clinical features was calculated. PATIENTS AND
participantsTwenty-four PCPIs (17 females, seven males) and 24 (12 females, 12 males) age-, sex-, and education-matched GSs. MEASUREMENTS AND
resultsPCPIs disturbed subjective sleep quality, split positive mood, and exacerbated negative moods. Compared with GSs, PCPIs showed higher ReHo in left fusiform gyrus, and lower ReHo in bilateral cingulate gyrus and right cerebellum anterior lobe. Compared with female GSs, female PCPIs showed higher ReHo in the left fusiform gyrus and right posterior cingulate, and lower ReHo in the left cerebellum anterior lobe and left superior frontal gyrus. Compared with male GSs, male PCPIs showed higher ReHo in the right temporal lobe and lower ReHo in the bilateral frontal lobe. The fusiform gyrus showed strong positive correlations and the frontal lobe showed negative correlations with the clinical measurements.
conclusionThe ReHo analysis is a useful noninvasive imaging tool for the detection of cerebral changes and the indexing of clinical features. The abnormal spontaneous activity areas provided important information on the neural mechanisms underlying emotion and sleep-quality impairment in PCPIs.
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