ArticleDisease markers2014
Influence of adiposity-related genetic markers in a population of saudi arabians where other variables influencing obesity may be reduced.
Article in Disease markers, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
15 citing papers in PubMed, 3 syntheses or guidelines pooled it, 28 citations in OpenAlex.
- Single nucleotide polymorphisms (SNPs) that are associated with obesity and type 2 diabetes among Asians: a systematic review and meta-analysis.Scientific reports · 2024Pooled it
- Prevalence, risk factors, and interventions for obesity in Saudi Arabia: A systematic review.Obesity reviews : an official journal of the International Association for the Study of Obesity · 2022Pooled it
- Associations ofNutrients · 2019Pooled it
- The impact of the BDNF Val66Met genotype on intrusive memories following trauma exposure and in PTSD is moderated by sex and timing of trauma exposure.Scientific reports · 2025Article
- Interaction of common variants of FTO gene and Dietary Inflammatory Index on obesity measures: Tehran Lipid and Glucose Study.BMJ nutrition, prevention & health · 2023Article
- The Association between Brain-Derived Neurotrophic Factor (BDNF) Protein Level and Body Mass Index.Medicina (Kaunas, Lithuania) · 2022Article
- Influence ofAging and disease · 2020Review
- Screening for obesity in the offspring of first-cousin consanguineous couples: A Phase-I study in Saudi Arabia.Saudi journal of biological sciences · 2020Article
- Article
- Molecular genetic studies in Saudi population; identified variants from GWAS and meta-analysis in stroke.Saudi journal of biological sciences · 2018Article
- The interaction of fat mass and obesity associated gene polymorphisms and dietary fiber intake in relation to obesity phenotypes.Scientific reports · 2017Article
- Mediterranean Dietary Pattern Adherence Modify the Association between FTO Genetic Variations and Obesity Phenotypes.Nutrients · 2017Article
- Association between 28 single nucleotide polymorphisms and type 2 diabetes mellitus in the Kazakh population: a case-control study.BMC medical genetics · 2017Article
- Children's Physical Activity Awareness among Mothers in a Saudi Arabian Health Center.Journal of clinical and diagnostic research : JCDR · 2017Article
- Assessment of the environmental and genetic factors influencing prevalence of metabolic syndrome in Saudi Arabia.Saudi medical journal · 2016Review
Corrections and comments
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Authors and funding
10 authors at 3 institutions in 2 countries.
Funding
Abstract
Large scale studies in Europeans have clearly identified common polymorphism affecting BMI and obesity. We undertook a genotype study to examine the impact of variants, known to influence obesity, in a sample from the Saudi Arabian population, notable for its profound combination of low mean physical activity indices and high energy intake. Anthropometry measures and genotypes were obtained for 367 Saudis, taken from King Saud University and Biomarker Screening Project in Riyadh (Riyadh Cohort). We observed large effect sizes with obesity for rs10767664 (BDNF) (OR = 1.923, P = 0.00072) and rs3751812 (FTO) (OR = 1.523, P = 0.016) in our sample and, using weighted genetic risk scores, we found strong evidence of a cumulative effect using 11 SNPs taken predominantly from loci principally affecting appetite (OR = 2.57, P = 0.00092). We used conditional analyses to discern which of our three highly correlated FTO SNPs were responsible for the observed signal, although we were unable to determine with confidence which best marked the causal site. Our analysis indicates that markers located in loci known to influence fat mass through increased appetite affect obesity in Saudi Arabians to an extent possibly greater than in Europeans. Larger scale studies will be necessary to obtain a precise comparison.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.