ArticleNature communications2014
Long-range ordered vorticity patterns in living tissue induced by cell division.
Article in Nature communications, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed.
- A principal-stress rule for cell division in epithelia.Nature communications · 2026Article
- Cell division sets a universal flow geometry in cell layers.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Liquid crystal-like self-organization of glioblastoma is associated with consistent migration for high cell densities.Scientific reports · 2026Article
- Mechanical state transitions in the regulation of tissue form and function.Nature reviews. Molecular cell biology · 2024Review
- E-cadherin biomaterials reprogram collective cell migration and cell cycling by forcing homeostatic conditions.Cell reports · 2024Article
- MACC1-induced migration in tumors: Current state and perspective.Frontiers in oncology · 2023Review
- Jamming Transitions in Astrocytes and Glioblastoma Are Induced by Cell Density and Tension.Cells · 2022Article
- Mechanical regulation of cell-cycle progression and division.Trends in cell biology · 2022Review
- MACC1-Induced Collective Migration Is Promoted by Proliferation Rather Than Single Cell Biomechanics.Cancers · 2022Article
- Are cell jamming and unjamming essential in tissue development?Cells & development · 2021Review
- The nature of cell division forces in epithelial monolayers.The Journal of cell biology · 2021Article
- Cell cycle-dependent active stress drives epithelia remodeling.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Active phase field crystal systems with inertial delay and underdamped dynamics.The European physical journal. E, Soft matter · 2020Article
- The role of single cell mechanical behavior and polarity in driving collective cell migration.Nature physics · 2020Article
- Influence of proliferation on the motions of epithelial monolayers invading adherent strips.Soft matter · 2019Article
- Mechanobiology of collective cell behaviours.Nature reviews. Molecular cell biology · 2017Review
- Article
- Dynamics of cancerous tissue correlates with invasiveness.Scientific reports · 2017Article
- Generalized Swift-Hohenberg models for dense active suspensions.The European physical journal. E, Soft matter · 2016Article
- Dynamics of Cell Ensembles on Adhesive Micropatterns: Bridging the Gap between Single Cell Spreading and Collective Cell Migration.PLoS computational biology · 2016Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In healthy blood vessels with a laminar blood flow, the endothelial cell division rate is low, only sufficient to replace apoptotic cells. The division rate significantly increases during embryonic development and under halted or turbulent flow. Cells in barrier tissue are connected and their motility is highly correlated. Here we investigate the long-range dynamics induced by cell division in an endothelial monolayer under non-flow conditions, mimicking the conditions during vessel formation or around blood clots. Cell divisions induce long-range, well-ordered vortex patterns extending several cell diameters away from the division site, in spite of the system's low Reynolds number. Our experimental results are reproduced by a hydrodynamic continuum model simulating division as a local pressure increase corresponding to a local tension decrease. Such long-range physical communication may be crucial for embryonic development and for healing tissue, for instance around blood clots.
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