Evidence map›Paper›PMID 25483466›Full record

ArticleHuman vaccines & immunotherapeutics2014

Could vaccination with AIDSVAX immunogens have resulted in antibody-dependent enhancement of HIV infection in human subjects?

Evgeny Shmelkov, Arthur Nadas, Timothy Cardozo

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Human vaccines & immunotherapeutics, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.5field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 9 citations in OpenAlex.

  1. Review
  2. Viral-Induced Enhanced Disease Illness.Frontiers in microbiology · 2018
    Review
  3. Article
  4. Response to letter to the editor.Human vaccines & immunotherapeutics · 2015
    Article
  5. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Evgeny Shmelkova Department of Biochemistry and Molecular Pharmacology ; New York University School of Medicine ; New York , NY USA.
Arthur Nadas
Timothy Cardozo
New York Proton Center · US

Funding

Combined cocaine and HIV vaccineDP1DA036478 · NIDA · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI CARDOZO, TIMOTHY J · 2013 to 2017
$4.7M
Structure-Based Characterization of gp120 Non-V3 Variable Loop EpitopesR01AI084119 · NIAID · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI CARDOZO, TIMOTHY J, KONG, XIANGPENG · 2009 to 2014
$3.2M
NIAID NIH HHS R01 AI084119NIAID NIH HHS R01AI084119NIDA NIH HHS DP1 DA036478NIDA NIH HHS DP1DA036478
6 · The paper itself

Abstract

The immune-correlate analysis of the RV144 clinical trial revealed that human plasma IgA immune responses elicited by the RV144 vaccine correlated positively with a risk for HIV acquisition. This result once again emphasized that HIV vaccines can potentially have adverse effects leading to enhancement of infection. Here, we discuss previously reported evidence of antibody-dependent enhancement of HIV infection. We also describe how a structure-based epitope-specific sieve-analysis can be employed to mine the molecular mechanism underlying this phenomenon.

Indexed as

AIDS VaccinesAntibody-Dependent EnhancementHIV-1HIV AntibodiesHIV Envelope Protein gp120HIV InfectionsHumansImmunoglobulin AVaccinationAIDS VaccinesAIDSVAXHIV AntibodiesHIV Envelope Protein gp120Immunoglobulin Aantibodyantibody-dependent enhancement of infectionantibody epitopesHIV vaccineHIV vaccine clinical trials

Identifiers

PMID25483466
PMCPMC5443089
OpenAlexW1999624920

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.