ArticleJournal of controlled release : official journal of the Controlled Release Society2015
Multi-modal contributions to detoxification of acute pharmacotoxicity by a triglyceride micro-emulsion.
Article in Journal of controlled release : official journal of the Controlled Release Society, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
35 citing papers in PubMed, 2 syntheses or guidelines pooled it, 114 citations in OpenAlex.
- Systematic Review and Meta-Analysis of Lipid Emulsion for Non-Local Anesthetic Poisoning.Journal of medical toxicology : official journal of the American College of Medical Toxicology · 2026Pooled it
- Effectiveness of treatments for propranolol toxicity: a systematic review of current approaches and evidence.European journal of clinical pharmacology · 2026Pooled it
- The impact of local anesthetic systemic toxicity advisories on reporting to the National Poison Data System (NPDS).Regional anesthesia and pain medicine · 2026Article
- Case Report: Lidocaine Toxicity Presenting with Focal Neurologic Findings.Clinical practice and cases in emergency medicine · 2026Article
- Use of intravenous lipid emulsions in drug-induced toxicities: a 2025 narrative review.Annals of intensive care · 2025Review
- Intralipid emulsion therapy for ivermectin toxicity in a dog.Veterinary medicine and science · 2025Article
- Local anesthetic systemic toxicity: awareness, recognition, and risk mitigation in the emergency department.Clinical and experimental emergency medicine · 2024Article
- AnBJA open · 2024Article
- Management of acute carbamazepine poisoning: A narrative review.World journal of psychiatry · 2023Review
- Mechanisms underlying lipid emulsion resuscitation for drug toxicity: a narrative review.Korean journal of anesthesiology · 2023Review
- Lipid emulsion for xenobiotic overdose: PRO.British journal of clinical pharmacology · 2023Article
- Lipid Emulsion to Treat Acute Poisonings: Mechanisms of Action, Indications, and Controversies.Pharmaceutics · 2023Review
- Opinion paper: gynecological surgery in local anesthesia?Archives of gynecology and obstetrics · 2022Article
- A Myriad of Symptoms After Spinal Anesthesia: A Case Report of Local Anesthetic Systemic Toxicity.Cureus · 2022Article
- Cardiac Arrest after Small Doses Ropivacaine: Local Anesthetic Systemic Toxicity in the Course of Continuous Femoral Nerve Blockade.International journal of environmental research and public health · 2022Article
- A case of refractory ventricular fibrillation after caffeine poisoning successfully treated by supportive care.Toxicology reports · 2022Article
- Predicting Inter-individual Variability During Lipid Resuscitation of Bupivacaine Cardiotoxicity in Rats: A Virtual Population Modeling Study.Drugs in R&D · 2021Article
- First Case of Acute Poisoning with Amiodarone and Flecainide in Attempted Suicide Successfully Managed with Lipid Emulsion Therapy in the Emergency Department: Case Report and Literature Review.Healthcare (Basel, Switzerland) · 2021Article
- Mechanisms and Efficacy of Intravenous Lipid Emulsion Treatment for Systemic Toxicity From Local Anesthetics.Frontiers in medicine · 2021Review
- [Stocktaking of local anesthetics 2020].Der Anaesthesist · 2020Review
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Authors and funding
10 authors at 2 institutions in 1 country.
Funding
Abstract
Triglyceride micro-emulsions such as Intralipid® have been used to reverse cardiac toxicity induced by a number of drugs but reservations about their broad-spectrum applicability remain because of the poorly understood mechanism of action. Herein we report an integrated mechanism of reversal of bupivacaine toxicity that includes both transient drug scavenging and a cardiotonic effect that couple to accelerate movement of the toxin away from sites of toxicity. We thus propose a multi-modal therapeutic paradigm for colloidal bio-detoxification whereby a micro-emulsion both improves cardiac output and rapidly ferries the drug away from organs subject to toxicity. In vivo and in silico models of toxicity were combined to test the contribution of individual mechanisms and reveal the multi-modal role played by the cardiotonic and scavenging actions of the triglyceride suspension. These results suggest a method to predict which drug toxicities are most amenable to treatment and inform the design of next-generation therapeutics for drug overdose.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.