Evidence map›Paper›PMID 25483406›Full record

ReviewTranscription2014

Regulatory SNPs and transcriptional factor binding sites in ADRBK1, AKT3, ATF3, DIO2, TBXA2R and VEGFA.

Norman E Buroker

Open access · bronzeAbstract readReview
In one paragraph

Review in Transcription, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
1.7field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 29 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author at 1 institution in 1 country.

Norman E Burokera Department of Pediatrics , University of Washington , Seattle , WA USA.
University of Washington · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Abstract Regulatory single nucleotide polymorphisms (rSNPs) which change the transcriptional factor binding sites (TFBS) for transcriptional factors (TFs) to bind DNA were reviewed for the ADRBK1 (GRK2), AKT3, ATF3, DIO2, TBXA2R and VEGFA genes. Changes in the TFBS where TFs attach to regulate these genes may result in human sickness and disease. The highlights of this previous work were reviewed for these genes.

Indexed as

Polymorphism, Single NucleotideActivating Transcription Factor 3Binding SitesGenome-Wide Association StudyG-Protein-Coupled Receptor Kinase 2HumansIodide PeroxidaseIodothyronine Deiodinase Type IIProto-Oncogene Proteins c-aktReceptors, Thromboxane A2, Prostaglandin H2Transcription FactorsUntranslated RegionsVascular Endothelial Growth Factor AActivating Transcription Factor 3AKT3 protein, humanATF3 protein, humanG-Protein-Coupled Receptor Kinase 2GRK2 protein, humanIodide PeroxidaseIodothyronine Deiodinase Type IIProto-Oncogene Proteins c-aktReceptors, Thromboxane A2, Prostaglandin H2Transcription FactorsUntranslated RegionsVascular Endothelial Growth Factor AVEGFA protein, humanADRBK1AKT3ATF3DIO2rSNPsTBXA2R and VEGFA genestranscriptional factor binding sitetranscriptional factors

Identifiers

PMID25483406
PMCPMC4581348
OpenAlexW2032040707

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.