Evidence map›Paper›PMID 25483404›Full record

ReviewTranscription2014

Long non-coding RNAs as emerging regulators of differentiation, development, and disease.

Bijan K Dey, Adam C Mueller, Anindya Dutta

Abstract readReview
In one paragraph

Review in Transcription, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 193 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
193citing papers in PubMed, 4 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

193 citing papers in PubMed, 4 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Review
  6. LncRNA Knockdown Using Gapmer Antisense Oligonucleotides.Methods in molecular biology (Clifton, N.J.) · 2026
    Article
  7. Article
  8. Article
  9. Article
  10. Regulation of the lncRNANAR molecular medicine · 2025
    Article
  11. Review
  12. Article
  13. Computational and structural biotechnology journal · 2024
    Review
  14. METTL3-mediated m6A modification enhances lncRNA H19 stability to promote endothelial cell inflammation and pyroptosis to aggravate atherosclerosis.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2024
    Article
  15. Article
  16. Article
  17. Iranian journal of public health · 2024
    Article
  18. Article
  19. Article
  20. Article

133 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Bijan K Deya Department of Biochemistry and Molecular Genetics ; University of Virginia School of Medicine ; Charlottesville , VA USA.
Adam C Mueller
Anindya Dutta

Funding

VEGF, FAK and RAPP01CA104106 · NCI · UNIVERSITY OF VIRGINIA CHARLOTTESVILLE · PI PASCHAL, BRYCE, THEODORESCU, DAN · 2005 to 2015
$17.9M
Cancer Research Training Program: From Molecular Mechanisms to Therapeutic StrategiesT32CA009109 · NCI · UNIVERSITY OF VIRGINIA CHARLOTTESVILLE · PI Andrew Carl Dudley, Melanie R Rutkowski · 1985 to 2026
$13.9M
MEDICAL SCIENTIST TRAINING PROGRAMT32GM007267 · NIGMS · UNIVERSITY OF VIRGINIA CHARLOTTESVILLE · PI GARCIA-BLANCO, MARIANO A. · 1985 to 2024
$13.4M
MicroRNAs in differentiation of muscleR01AR053948 · NIAMS · UNIVERSITY OF VIRGINIA · PI DUTTA, ANINDYA · 2007 to 2011
$1.7M
NCI NIH HHS T32 CA009109
6 · The paper itself

Abstract

A significant portion of the mammalian genome encodes numerous transcripts that are not translated into proteins, termed long non-coding RNAs. Initial studies identifying long non-coding RNAs inferred these RNA sequences were a consequence of transcriptional noise or promiscuous RNA polymerase II activity. However, the last decade has seen a revolution in the understanding of regulation and function of long non-coding RNAs. Now it has become apparent that long non-coding RNAs play critical roles in a wide variety of biological processes. In this review, we describe the current understanding of long non-coding RNA-mediated regulation of cellular processes: differentiation, development, and disease.

Indexed as

Alternative SplicingAnimalsCell DifferentiationGene Expression RegulationHumansMicroRNAsMuscle, SkeletalMuscular DystrophiesRNA, Long NoncodingMicroRNAsRNA, Long NoncodingXIST non-coding RNABvht, braveheartCDT, C-terminal domainceRNAs, competing endogenous RNAsciRS-7, circular RNA sponge for miR-7DBE-T, D4Z4-binding elementdevelopmentdifferentiationdiseaseDMD, Duchenne muscular dystrophyES, embryonic stemFendrr, Foxf1a called fetal-lethal non-coding developmental regulatory RNAFSHD, facioscapulohumeral muscular dystrophygene expressioniPS, induced pluripotent stemlncRNAs, long non-coding RNAslong non-coding RNAsMalat1, metastasis associated lung adenocarcinoma transcript 1MEF2, myocyte enhancer factor-2Mesp1, mesoderm progenitor 1MRFs, myogenic regulatory factorsncRNAa, non-coding RNA activatingNeat2, nuclear-enriched abundant transcript 2PRC2, polycomb group repressive complex 2RNAP II, RNA polymerase IISINE, short interspersed elementskeletal muscleSRA, steroid receptor activatorSR, serine arginineSRY, sex-determining region YYAM 1-4, YY1-associated muscle 1-4

Identifiers

PMID25483404
PMCPMC4581346

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.