ArticleInternational wound journal2016
Aetiology, comorbidities and cofactors of chronic leg ulcers: retrospective evaluation of 1 000 patients from 10 specialised dermatological wound care centers in Germany.
Article in International wound journal, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 2 of them syntheses that pooled it.
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Who cites it
28 citing papers in PubMed, 2 syntheses or guidelines pooled it, 105 citations in OpenAlex.
- Compression bandages or stockings versus no compression for treating venous leg ulcers.The Cochrane database of systematic reviews · 2021Pooled it
- Social participation of people with chronic wounds: A systematic review.International wound journal · 2021Pooled it
- Content validation of the Wound-QoL questionnaire measuring quality of life in chronic wounds - a qualitative study in patients with leg ulcers and diabetic foot ulcers.Journal of patient-reported outcomes · 2025Article
- Profiling Patients with Chronic Ulcers Using K-Means Clustering and Analysis of the Impact on the Consumption of Medical Resources: Retrospective Study on Hospitalized Patients in Romania.Journal of clinical medicine · 2025Article
- A Review of Chronic Wounds and Their Impact on Negative Affect, Cognition, and Quality of Life.International wound journal · 2025Review
- Lyophilized Extract from the Larvae of the BlowflyBiomedicines · 2025Article
- Characteristics of chronic ulcer patients by gender and ulcer aetiology from a multidisciplinary wound centre.International wound journal · 2024Article
- One Molecule, Many Faces: Repositioning Cardiovascular Agents for Advanced Wound Healing.Molecules (Basel, Switzerland) · 2024Review
- The Impact of Underlying Conditions on Quality-of-Life Measurement Among Patients with Chronic Wounds, as Measured by Utility Values: A Review with an Additional Study.Advances in wound care · 2023Review
- [The crucial role of color-coded duplex sonography before planning microvascular tissue transfer in the lower extremities].Der Unfallchirurg · 2022Article
- Assessment of frailty in elderly patients attending a multidisciplinary wound care centre: a cohort study.BMC geriatrics · 2021Article
- Association of wound genesis on varying aspects of health-related quality of life in patients with different types of chronic wounds: Results of a cross-sectional multicentre study.International wound journal · 2021Article
- Long-term Mortality among Patients with Chronic Ulcers.Acta dermato-venereologica · 2021Article
- Article
- [Long-term healing of a therapy-refractory venous leg ulcer after crural fasciectomy and split skin graft transplantation].Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete · 2021Article
- The use of intermittent pneumatic compression of the thigh to affect arterial and venous blood flow proximal to a chronic wound site.International wound journal · 2020Article
- Prospective clinical study on the efficacy of bacterial removal with mechanical debridement in and around chronic leg ulcers assessed with fluorescence imaging.International wound journal · 2020Article
- Concomitant chronic venous insufficiency in patients with peripheral artery disease: insights from MR angiography.European radiology · 2020Article
- Review
- Peripheral arterial disease: Scoping review of patient-centred outcomes.International wound journal · 2019Article
Corrections and comments
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Authors and funding
13 authors at 11 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Numerous comorbidities and cofactors have been known to influence wound healing processes. In this multicentre study, clinical data of 1 000 patients with chronic leg ulcers from ten specialised dermatological wound care centers were analysed. The patient cohort comprised 567 females and 433 males with an average age of 69·9 years. The wounds persisted on average for 40·8 months and had a mean size of 43·7 cm(2) . Venous leg ulcers represented the most common entity accounting for 51·3% of all chronic wounds, followed by mixed-type ulcers in 12·9% and arterial ulcerations in 11·0% of the patients. Vasculitis was diagnosed in 4·5%, trauma in 3·2%, pyoderma gangrenosum in 2·8%, lymphoedema in 1·7%, neoplasia in 1·0% and delayed post-surgical wound healing in 0·6% of the included patients. In total, 70·5% of patients suffered from arterial hypertension, 45·2% were obese, 27·2% had non-insulin dependent diabetes, and 24·4% dyslipidaemia. Altogether 18·4% suffered from metabolic syndrome. Cofactors and comorbidities of patients with chronic leg ulcers have previously been studied but not in detail. Here, we were able to demonstrate the existence of several potentially relevant cofactors, comorbidities of their associations and geographical distributions, which should be routinely examined in patients with chronic leg ulcers and - if possible - treated.
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