ReviewGut microbes2014
Gut microbes and adverse food reactions: Focus on gluten related disorders.
Review in Gut microbes, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 39 citations in OpenAlex.
- Microscopic enteritis: Bucharest consensus.World journal of gastroenterology · 2015Guideline
- High fat diet increases the severity of collagen-induced arthritis in mice by altering the gut microbial community.Advances in rheumatology (London, England) · 2024Article
- Review
- The mucosal immune system and IgA nephropathy.Seminars in immunopathology · 2021Review
- Gut Microbiota, the Immune System, and Cytotoxic T Lymphocytes.Methods in molecular biology (Clifton, N.J.) · 2021Article
- Role of the gut microbiota in the pathogenesis of coeliac disease and potential therapeutic implications.European journal of nutrition · 2020Review
- Non-Responsive Coeliac Disease: A Comprehensive Review from the NHS England National Centre for Refractory Coeliac Disease.Nutrients · 2020Review
- Gut Microbiota Dysbiosis Enhances Migraine-Like Pain Via TNFα Upregulation.Molecular neurobiology · 2020Article
- The Gut Microbiota in Celiac Disease and probiotics.Nutrients · 2019Review
- Microbiota in the Gastrointestinal Tract.Medical sciences (Basel, Switzerland) · 2018Review
- First Insights into the Gut Microbiota of Mexican Patients with Celiac Disease and Non-Celiac Gluten Sensitivity.Nutrients · 2018Article
- Dietary Effects on Microbiota-New Trends with Gluten-Free or Paleo Diet.Medical sciences (Basel, Switzerland) · 2018Review
- Oral Health Impact Profile in Celiac Patients: Analysis of Recent Findings in a Literature Review.Gastroenterology research and practice · 2018Review
- Dysbiosis a risk factor for celiac disease.Medical microbiology and immunology · 2017Review
- PPARgamma Deficiency Counteracts Thymic Senescence.Frontiers in immunology · 2017Article
- Role of the Gut Microbiome in Modulating Arthritis Progression in Mice.Scientific reports · 2016Article
- Impact of Gluten-Friendly Bread on the Metabolism and Function of In Vitro Gut Microbiota in Healthy Human and Coeliac Subjects.PloS one · 2016Article
- Innate immunity: actuating the gears of celiac disease pathogenesis.Best practice & research. Clinical gastroenterology · 2015Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Immediately following birth, the gastrointestinal tract is colonized with a complex community of bacteria, which helps shape the immune system. Under conditions of health, the immune system is able to differentiate between innocuous antigens, including food protein and commensals, and harmful antigens such as pathogens. However, patients with celiac disease (CD) develop an intolerance to gluten proteins which results in a pro-inflammatory T-cell mediated immune response with production of anti-gluten and anti-tissue transglutaminase antibodies. This adaptive immune response, in conjunction with activation of innate inflammatory cells, lead to destruction of the small intestinal mucosa. Overall 30% of the global population has genetic risk to develop CD. However, only a small proportion develop CD, suggesting that additional environmental factors must play a role in disease pathogenesis. Alterations in small intestinal microbial composition have recently been associated with active CD, indicating a possible role for the microbiota in CD. However, studies demonstrating causality are lacking. This review will highlight the recent data on the potential role of the microbiota in CD pathogenesis, the potential mechanisms, and discuss future research directions.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.