ArticleChannels (Austin, Tex.)2014
Caffeine-induced Ca(2+) oscillations in type I horizontal cell of carp retina: a mathematical model.
Article in Channels (Austin, Tex.), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Oscillations in intracellular free Ca(2+) concentration ([Ca(2+)]i) have been observed in a variety of cell types. In the present study, we constructed a mathematical model to simulate the caffeine-induced [Ca(2+)]i oscillations based on experimental data obtained from isolated type I horizontal cell of carp retina. The results of model analysis confirm the notion that the caffeine-induced [Ca(2+)]i oscillations involve a number of cytoplasmic and endoplasmic Ca(2+) processes that interact with each other. Using this model, we evaluated the importance of store-operated channel (SOC) in caffeine-induced [Ca(2+)]i oscillations. The model suggests that store-operated Ca(2+) entry (SOCE) is elicited upon depletion of the endoplasmic reticulum (ER). When the SOC conductance is set to 0, caffeine-induced [Ca(2+)]i oscillations are abolished, which agrees with the experimental observation that [Ca(2+)]i oscillations were abolished when SOC was blocked pharmacologically, verifying that SOC is necessary for sustained [Ca(2+)]i oscillations.
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