ArticleFly2014
Fruitless isoforms and target genes specify the sexually dimorphic nervous system underlying Drosophila reproductive behavior.
Article in Fly, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
10 citing papers in PubMed, 25 citations in OpenAlex.
- Social experience and pheromone receptor activity reprogram gene expression in sensory neurons.G3 (Bethesda, Md.) · 2023Article
- Sex determination geneeLife · 2021Article
- A non-coding indel polymorphism in theProceedings. Biological sciences · 2021Article
- Investigation ofeLife · 2021Article
- Article
- Distinct Roles and Synergistic Function of FruCell reports · 2020Article
- Regulation of olfactory-based sex behaviors in the silkworm by genes in the sex-determination cascade.PLoS genetics · 2020Article
- Article
- Sexual dimorphism of sleep regulated by juvenile hormone signaling in Drosophila.PLoS genetics · 2018Article
- Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
Abstract
Courtship is pivotal to successful reproduction throughout the animal kingdom. Sexual differences in the nervous system are thought to underlie courtship behavior. Male courtship behavior in Drosophila is in large part regulated by the gene fruitless (fru). fru has been reported to encode at least three putative BTB-zinc-finger transcription factors predicted to have different DNA-binding specificities. Although a large number of previous studies have demonstrated that fru plays essential roles in male courtship behavior, we know little about the function of Fru isoforms at the molecular level. Our recent study revealed that male-specific Fru isoforms are expressed in highly overlapping subsets of neurons in the male brain and ventral nerve cord. Fru isoforms play both distinct and redundant roles in male courtship behavior. Importantly, we have identified for the first time, by means of the DamID technique, direct Fru transcriptional target genes. Fru target genes overwhelmingly represent genes previously reported to be involved in the nervous system development, such as CadN, lola and pdm2. Our study provides important insight into how the sexually dimorphic neural circuits underlying reproductive behavior are established.
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Registered trials
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