ArticleClinical oral investigations2015
Development of resistance of mutans streptococci and Porphyromonas gingivalis to chlorhexidine digluconate and amine fluoride/stannous fluoride-containing mouthrinses, in vitro.
Article in Clinical oral investigations, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 51 citations in OpenAlex.
- Streptococcus dentisani and Streptococcus mutans in dental biofilm of preschoolers with and without early childhood caries: a cross-sectional study.European archives of paediatric dentistry : official journal of the European Academy of Paediatric Dentistry · 2026Article
- When Disinfection Fails: Biocide Tolerance as a Driver ofAntibiotics (Basel, Switzerland) · 2026Review
- Antiseptics Prescription for the Prevention and Treatment of Periodontal Diseases: A Comprehensive Review.Health science reports · 2025Article
- The influence of diet, saliva, and dental history on the oral microbiome in healthy, caries-free Australian adults.Scientific reports · 2025Article
- The effects of nitrate on the oral microbiome: a systematic review investigating prebiotic potential.Journal of oral microbiology · 2024Review
- Mouthwash Effects on the Oral Microbiome: Are They Good, Bad, or Balanced?International dental journal · 2023Review
- Effects of topical fluoride application on oral microbiota in young children with severe dental caries.Frontiers in cellular and infection microbiology · 2023Article
- The influence of biofilm maturation on fluoride's anticaries efficacy.Clinical oral investigations · 2022Article
- Antimicrobial Activity ofAntibiotics (Basel, Switzerland) · 2022Article
- Sequential Application of Calcium Phosphate and ε-Polylysine Show Antibacterial and Dentin Tubule Occluding Effects In Vitro.International journal of molecular sciences · 2021Article
- Potential prebiotic substrates modulate composition, metabolism, virulence and inflammatory potential of an in vitro multi-species oral biofilm.Journal of oral microbiology · 2021Article
- Biocide Use in the Antimicrobial Era: A Review.Molecules (Basel, Switzerland) · 2021Review
- Antimicrobial activities of a small molecule compound II-6s against oral streptococci.Journal of oral microbiology · 2021Article
- Efficacy of Experimental Mouth Rinses on Caries-Related BiofilmsFrontiers in oral health · 2021Article
- Antimicrobial Activity, Biocompatibility and Anti-inflammatory Properties of Cetylpyridinium Chloride-based Mouthwash Containing Sodium Fluoride and Xylitol: An In Vitro Study.Oral health & preventive dentistry · 2020Article
- Effect of Novel Antibacterial Composites on Bacterial Biofilms.Journal of functional biomaterials · 2020Article
- The Contribution of Photodynamic Inactivation vs. Corsodyl Mouthwash to the Control of Streptococcus mutans Biofilms.Current microbiology · 2020Article
- Antibacterial Effect of the Natural Polymer ε-Polylysine Against Oral Pathogens Associated with Periodontitis and Caries.Polymers · 2020Article
- Tolerance and Persister Formation in Oral Streptococci.Antibiotics (Basel, Switzerland) · 2020Article
- Development of antiseptic adaptation and cross-adapatation in selected oral pathogens in vitro.Scientific reports · 2019Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveThe aim if this study was to determine the minimal inhibitory concentrations of chlorhexidine digluconate and an amine fluoride/stannous fluoride-containing mouthrinse against Porphyromonas gingivalis and mutans streptococci during an experimental long-term subinhibitory exposition. MATERIAL AND
methodsFive P. gingivalis strains and four mutans streptococci were subcultivated for 20-30 passages in subinhibitory concentrations of chlorhexidine digluconate or an amine fluoride/stannous fluoride-containing mouthrinse.
resultsPre-passaging minimal inhibitory concentrations for chlorhexidine ranged from 0.5 to 2 mg/l for mutans streptococci and from 2 to 4 mg/l for the P. gingivalis isolates. For the amine fluoride/stannous fluoride-containing mouthrinse minimal inhibitory values from 0.125 to 0.25% for the mutans streptococci and from 0.063 to 0.125% for the P. gingivalis isolates were determined. Two- to fourfold increased minimal inhibitory concentrations against chlorhexidine were detected for two of the five P. gingivalis isolates, whereas no increase in minimal inhibitory concentrations was found for the mutans streptococci after repeated passaging through subinhibitory concentrations. Repeated exposure to subinhibitory concentrations of the amine fluoride/stannous fluoride-containing mouthrinse did not alter the minimally inhibitory concentrations of the bacterial isolates tested.
conclusionChlorhexidine and the amine fluoride/stannous fluoride-containing mouthrinse are effective inhibitory agents against the oral bacterial isolates tested. No general development of resistance against chlorhexidine or the amine fluoride/stannous fluoride-containing mouthrinse was detected. However, some strains showed potential to develop resistance against chlorhexidine after prolonged exposure. CLINICAL RELEVANCE: The use of chlorhexidine should be limited to short periods of time. The amine fluoride/stannous fluoride-containing mouthrinse appears to have the potential to be used on a long-term basis.
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