ArticleCell cycle (Georgetown, Tex.)2014
Inactivation of the budding yeast cohesin loader Scc2 alters gene expression both globally and in response to a single DNA double strand break.
Article in Cell cycle (Georgetown, Tex.), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 13 citations in OpenAlex.
- Evaluating the efficacy of probiotics in treating Parkinson's disease model rats using magnetic resonance enhanced gradient echo T2-weighted angiography sequence.Frontiers in neuroscience · 2025Article
- Cohesin-dependent chromosome loop extrusion is limited by transcription and stalled replication forks.Science advances · 2022Article
- Recruitment of Scc2/4 to double-strand breaks depends on γH2A and DNA end resection.Life science alliance · 2022Article
- Deficiency of Polη in Saccharomyces cerevisiae reveals the impact of transcription on damage-induced cohesion.PLoS genetics · 2021Article
- Transcriptional responses to DNA damage.DNA repair · 2019Review
- Error-free DNA damage tolerance pathway is facilitated by the Irc5 translocase through cohesin.The EMBO journal · 2018Article
- New insights into cohesin loading.Current genetics · 2018Review
- The SMC Loader Scc2 Promotes ncRNA Biogenesis and Translational Fidelity.PLoS genetics · 2015Article
- The SMC loader Scc2 regulates gene expression.Cell cycle (Georgetown, Tex.) · 2015Article
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5 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Genome integrity is fundamental for cell survival and cell cycle progression. Important mechanisms for keeping the genome intact are proper sister chromatid segregation, correct gene regulation and efficient repair of damaged DNA. Cohesin and its DNA loader, the Scc2/4 complex have been implicated in all these cellular actions. The gene regulation role has been described in several organisms. In yeast it has been suggested that the proteins in the cohesin network would effect transcription based on its role as insulator. More recently, data are emerging indicating direct roles for gene regulation also in yeast. Here we extend these studies by investigating whether the cohesin loader Scc2 is involved in regulation of gene expression. We performed global gene expression profiling in the absence and presence of DNA damage, in wild type and Scc2 deficient G2/M arrested cells, when it is known that Scc2 is important for DNA double strand break repair and formation of damage induced cohesion. We found that not only the DNA damage specific transcriptional response is distorted after inactivation of Scc2 but also the overall transcription profile. Interestingly, these alterations did not correlate with changes in cohesin binding.
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