Evidence map›Paper›PMID 25483045›Full record

ArticleRNA biology2014

Mir-23a and mir-125b regulate neural stem/progenitor cell proliferation by targeting Musashi1.

Ubaldo Gioia, Valerio Di Carlo, Pasquale Caramanica, Camilla Toselli, Antonella Cinquino, Marcella Marchioni, Pietro Laneve, Stefano Biagioni, Irene Bozzoni, Emanuele Cacci and 1 more

Open access · bronzeAbstract read
In one paragraph

Article in RNA biology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
1.6field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 33 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Review
  5. Article
  6. Article
  7. Article
  8. Article
  9. Review
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Review
  17. Article
  18. Article
  19. miR-761 inhibits tumor progression by targeting MSI1 in ovarian carcinoma.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2016
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 2 countries.

Ubaldo Gioiaa Deptartment of Biology and Biotechnology Charles Darwin ; Sapienza University of Rome ; Rome, Italy.
Valerio Di Carlo
Pasquale Caramanica
Camilla Toselli
Antonella Cinquino
Marcella Marchioni
Pietro Laneve
Stefano Biagioni
Irene Bozzoni
Emanuele Cacci
Elisa Caffarelli
Sapienza University of Rome · ITItalian Institute of Technology · ITIstituto Pasteur · ITNanobiotix (France) · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Musashi1 is an RNA binding protein that controls the neural cell fate, being involved in maintaining neural progenitors in their proliferative state. In particular, its downregulation is needed for triggering early neural differentiation programs. In this study, we profiled microRNA expression during the transition from neural progenitors to differentiated astrocytes and underscored 2 upregulated microRNAs, miR-23a and miR-125b, that sinergically act to restrain Musashi1 expression, thus creating a regulatory module controlling neural progenitor proliferation.

Indexed as

Cell ProliferationGene Expression Regulation, DevelopmentalAnimalsBlotting, WesternCell DifferentiationCells, CulturedEmbryo, MammalianImmunoenzyme TechniquesMiceMicroRNAsNerve Tissue ProteinsNeural Stem CellsNeurogenesisReal-Time Polymerase Chain ReactionReverse Transcriptase Polymerase Chain ReactionRNA-Binding ProteinsMicroRNAsMirn125 microRNA, mouseMirn23b microRNA, mouseMsi1h protein, mouseNerve Tissue ProteinsRNA-Binding ProteinsRNA, Messenger3′UTR, 3′Untranslated Regionastrocyte differentiationBrdU, 5-bromo-2′-deoxyuridinecell proliferationmicroRNAsmiRNA, microRNAMsi1, Musashi1musashi1neural progenitorsNSPCs, Neural Stem/Progenitor Cellspost-transcriptional gene regulation

Identifiers

PMID25483045
PMCPMC4615800
OpenAlexW2075887783

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.