ArticleThe American journal of pathology2015
Astrocytic dynamin-like protein 1 regulates neuronal protection against excitotoxicity in Parkinson disease.
Article in The American journal of pathology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 33 citations in OpenAlex.
- Astrocytes in Parkinson's Disease: From Guardians to Accomplices.Clinical interventions in aging · 2026Review
- Mitochondria from huntington´s disease striatal astrocytes are hypermetabolic and compromise neuronal branching.Cell communication and signaling : CCS · 2025Article
- Drp1 mitochondrial fission in astrocyte modulates behavior and neuroinflammation during morphine addiction.Journal of neuroinflammation · 2025Article
- Energy metabolism in health and diseases.Signal transduction and targeted therapy · 2025Review
- Aging and MPTP Sensitivity Depend on Molecular and Ultrastructural Signatures of Astroglia and Microglia in Mice Substantia Nigra.Cellular and molecular neurobiology · 2025Article
- Heimdall, an alternative protein issued from a ncRNA related to kappa light chain variable region of immunoglobulins from astrocytes: a new player in neural proteome.Cell death & disease · 2023Article
- The reduction of astrocytic tau prevents amyloid-β-induced synaptotoxicity.Brain communications · 2022Article
- The neuroprotective effects of glucagon-like peptide 1 in Alzheimer's and Parkinson's disease: An in-depth review.Frontiers in neuroscience · 2022Review
- Study on the Mechanism of Liuwei Dihuang Pills in Treating Parkinson's Disease Based on Network Pharmacology.BioMed research international · 2021Article
- Erythrocytic α-synuclein contained in microvesicles regulates astrocytic glutamate homeostasis: a new perspective on Parkinson's disease pathogenesis.Acta neuropathologica communications · 2020Article
- Mitochondrial Dynamics and Bioenergetic Alteration During Inflammatory Activation of Astrocytes.Frontiers in aging neuroscience · 2020Article
- Time-effect relationship of acupuncture on histopathology, ultrastructure, and neuroethology in the acute phase of cerebral hemorrhage.Neural regeneration research · 2019Article
- Regulation of mitochondrial dynamics in astrocytes: Mechanisms, consequences, and unknowns.Glia · 2018Review
- Biological Implications of Differential Expression of Mitochondrial-Shaping Proteins in Parkinson's Disease.Antioxidants (Basel, Switzerland) · 2017Article
- Mfn2 protects dopaminergic neurons exposed to paraquat both in vitro and in vivo: Implications for idiopathic Parkinson's disease.Biochimica et biophysica acta. Molecular basis of disease · 2017Article
- Mortalin is Expressed by Astrocytes and Decreased in the Midbrain of Parkinson's Disease Patients.Brain pathology (Zurich, Switzerland) · 2016Article
- Neuron-Glia Crosstalk in the Autonomic Nervous System and Its Possible Role in the Progression of Metabolic Syndrome: A New Hypothesis.Frontiers in physiology · 2015Article
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Authors and funding
7 authors at 1 institution in 1 country.
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Abstract
Mitochondrial dynamics has recently become an area of piqued interest in neurodegenerative disorders, including Parkinson disease (PD); however, the contribution of astrocytes to these disorders remains unclear. Here, we show that the level of dynamin-like protein 1 (Dlp1; official name DNM1L), which promotes mitochondrial fission, is lower in astrocytes from the brains of PD patients, and that decreased astrocytic Dlp1 likely represents a relatively early event in PD pathogenesis. In support of this conclusion, we show that Dlp1 knockdown dramatically affects mitochondrial morphological characteristics and localization in astrocytes, impairs the ability of astrocytes to adequately protect neurons from the excitotoxic effects of glutamate, and increases intracellular Ca(2+) in response to extracellular glutamate, resulting from compromised intracellular Ca(2+) buffering. Taken together, our results suggest that astrocytic mitochondrial Dlp1 is a key protein in mitochondrial dynamics and decreased Dlp1 may interfere with neuron survival in PD by disrupting Ca(2+)-coupled glutamate uptake.
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