ReviewRNA biology2014
Unmasking the messenger.
Review in RNA biology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 39 citations in OpenAlex.
- Review
- RNA-Binding Proteins as Epigenetic Regulators of Brain Functions and Their Involvement in Neurodegeneration.International journal of molecular sciences · 2022Review
- Persistent up-regulation of polyribosomes at synapses during long-term memory, reconsolidation, and extinction of associative memory.Learning & memory (Cold Spring Harbor, N.Y.) · 2022Article
- Upregulation of eIF4E, but not other translation initiation factors, in dendritic spines during memory formation.The Journal of comparative neurology · 2021Article
- 4E-T-bound mRNAs are stored in a silenced and deadenylated form.Genes & development · 2020Article
- Staufen2-mediated RNA recognition and localization requires combinatorial action of multiple domains.Nature communications · 2019Article
- Neuronal messenger ribonucleoprotein transport follows an aging Lévy walk.Nature communications · 2018Article
- A retained intron in the 3'-UTR ofEMBO reports · 2017Article
- A Requirement for Mena, an Actin Regulator, in Local mRNA Translation in Developing Neurons.Neuron · 2017Article
- Accumulation of Polyribosomes in Dendritic Spine Heads, But Not Bases and Necks, during Memory Consolidation Depends on Cap-Dependent Translation Initiation.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2017Article
- Imaging Single-mRNA Localization and Translation in Live Neurons.Molecules and cells · 2016Review
- An amyotrophic lateral sclerosis-linked mutation in GLE1 alters the cellular pool of human Gle1 functional isoforms.Advances in biological regulation · 2016Article
- Dysregulation and restoration of translational homeostasis in fragile X syndrome.Nature reviews. Neuroscience · 2015Review
- Single-molecule insights into mRNA dynamics in neurons.Trends in cell biology · 2015Review
- Article
- Differentially expressed genes linked to natural variation in long-term memory formation in Cotesia parasitic wasps.Frontiers in behavioral neuroscience · 2015Article
- Meet the players: local translation at the synapse.Frontiers in molecular neuroscience · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Synaptic plasticity, learning, and memory require high temporal and spatial control of gene expression. These processes are thought to rely mainly on asymmetric mRNA transport to synapses. Already in the early days of studying mRNA transport, Wilhelm and Vale proposed a multi-step process in 1993. Since then, we have gained important novel insights into how these individual steps are controlled by research performed in various cell types and organisms. Here, we present the latest view on how dendritic mRNA localization is achieved and how local translation at the synapse is regulated. In particular, we propose that the recently observed heterogeneity of RNA-protein particle assembly in neurons might be the key for how precise gene expression in the brain is achieved. In addition, we focus on latest data dealing with translational activation of translationally repressed mRNPs at a synapse that experiences learning-induced changes in its morphology and function. Together, these new findings shed new light on how precise regulatory mechanisms can lead to synaptic plasticity and memory formation.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.