ArticleDevelopmental cell2014
The left-right Pitx2 pathway drives organ-specific arterial and lymphatic development in the intestine.
Article in Developmental cell, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 52 papers.
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Who cites it
52 citing papers in PubMed, 110 citations in OpenAlex.
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- Mechanisms and functions of intestinal vascular specialization.The Journal of experimental medicine · 2024Review
- Unraveling the lymphatic system in the spinal cord meninges: a critical element in protecting the central nervous system.Cellular and molecular life sciences : CMLS · 2023Review
- Neck Surgery for Non-Well Differentiated Thyroid Malignancies: Variations in Strategy According to Histopathology.Cancers · 2023Review
- Optogenetic control of gut movements reveals peristaltic wave-mediated induction of cloacal contractions and reactivation of impaired gut motility.Frontiers in physiology · 2023Article
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- The Development of the Mesenteric Model of Abdominal Anatomy.Clinics in colon and rectal surgery · 2022Review
- The asymmetric Pitx2 gene regulates gut muscular-lacteal development and protects against fatty liver disease.Cell reports · 2021Article
- The lymphatics in kidney health and disease.Nature reviews. Nephrology · 2021Review
- Pitx genes in development and disease.Cellular and molecular life sciences : CMLS · 2021Review
- The evolving cardiac lymphatic vasculature in development, repair and regeneration.Nature reviews. Cardiology · 2021Review
- Mechanisms and cell lineages in lymphatic vascular development.Angiogenesis · 2021Review
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
Abstract
The dorsal mesentery (DM) is the major conduit for blood and lymphatic vessels in the gut. The mechanisms underlying their morphogenesis are challenging to study and remain unknown. Here we show that arteriogenesis in the DM begins during gut rotation and proceeds strictly on the left side, dependent on the Pitx2 target gene Cxcl12. Although competent Cxcr4-positive angioblasts are present on the right, they fail to form vessels and progressively emigrate. Surprisingly, gut lymphatics also initiate in the left DM and arise only after-and dependent on-arteriogenesis, implicating arteries as drivers of gut lymphangiogenesis. Our data begin to unravel the origin of two distinct vascular systems and demonstrate how early left-right molecular asymmetries are translated into organ-specific vascular patterns. We propose a dual origin of gut lymphangiogenesis in which prior arterial growth is required to initiate local lymphatics that only subsequently connect to the vascular system.
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Registered trials
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