Evidence map›Paper›PMID 25482829›Full record

ReviewCell adhesion & migration2015

Tenascin-C: Form versus function.

Sean P Giblin, Kim S Midwood

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Cell adhesion & migration, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 137 papers.

0numbers the graph read from it
0cells of the map it votes in
137citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

137 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
  4. Article
  5. Review
  6. Article
  7. Article
  8. Article
  9. Review
  10. Article
  11. Article
  12. Article
  13. Article
  14. Deciphering the Tenascin-C Nexus: A Comprehensive Review of Its Involvement in Chronic Respiratory Diseases.Pathophysiology : the official journal of the International Society for Pathophysiology · 2025
    Review
  15. Article
  16. Article
  17. Article
  18. Review
  19. Article
  20. A CD26Nature communications · 2025
    Article

77 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Sean P Giblina Nuffield Department of Orthopaedics; Rheumatology and Musculoskeletal Sciences ; Kennedy Institute of Rheumatology; University of Oxford ; Oxford , UK.
Kim S Midwood

Funding

Arthritis Research UK 20003
6 · The paper itself

Abstract

Tenascin-C is a large, multimodular, extracellular matrix glycoprotein that exhibits a very restricted pattern of expression but an enormously diverse range of functions. Here, we discuss the importance of deciphering the expression pattern of, and effects mediated by, different forms of this molecule in order to fully understand tenascin-C biology. We focus on both post transcriptional and post translational events such as splicing, glycosylation, assembly into a 3D matrix and proteolytic cleavage, highlighting how these modifications are key to defining tenascin-C function.

Indexed as

AnimalsBrainGene Expression RegulationGene Regulatory NetworksHumansProtein Processing, Post-TranslationalSignal TransductionTenascinTenascinAD1/AD2, additional domain 1/ additional domain 2ADAMTS, a disintegrin and metalloproteinase with thrombospondin motifsASMCs, aortic smooth muscle cellsBDNF, brain derived neurotrophic factorbFGF, basic fibroblast growth factorBHKs, baby hamster kidney cellsbiosynthesisBMP, bone morphogenetic proteinCA19–9, carbohydrate antigen 19–9CALEB, chicken acidic leucine-rich EGF-like domain containing brain proteincancerc, chargedccRCC, clear cell renal cell carcinomaCEA, carcinoembryonic antigenchRCC, chromophobe-primary renal cell carcinomaCNS, central nervous systemCRC, colorectal carcinomasCTGF, connective tissue growth factorDCIS, ductal carcinoma in-situdevelopmentECM, extracellular matrixEDA-FN, extra domain A containing fibronectinEDB-FN, extra domain B containing fibronectinEGF-L, epidermal growth factor-likeEGF-R, epidermal growth factor receptorELISPOT, enzyme-linked immunospot assayFBG, fibrinogen-like globeFGF2, fibroblast growth factor 2FGF4, fibroblast growth factor 4FN, fibronectinFNIII, fibronectin type III-like repeatglycosylationGMEM, glioma-mesenchymal extracellular matrix antigenGPI, glycosylphosphatidylinositolHB-EGF, heparin-binding EGF-like growth factorHCEs, immortalized human corneal epithelial cell lineHGF, hepatocyte growth factorHNK-1, human natural killer-1HSPGs, heparan sulfate proteoglycansHUVECs, human umbilical vein endothelial cellsICC, immunocytochemistryIF, immunofluorescenceIFNγ, interferon gammaIGF-BP, insulin-like growth factor-binding proteinIGF, insulin-like growth factorIHC, immunohistochemistryIL, interleukinISH, in situ hybridizationLPS, lipopolysaccharidemAb, monoclonal antibodymatrix assemblymitogen-activated protein kinase, MAPKMMP, matrix metalloproteinaseMPNSTs, malignant peripheral nerve sheath tumorsMr, molecular massNB, northern blotNF-kB, nuclear factor kappa-light-chain-enhancer of activated B cellsNK, natural killer cellsNSCLC, non-small cell lung carcinomaNSCs, neural stem cellsNT, neurotrophinPAMPs, pathogen-associated molecular patternsPDGF, platelet derived growth factorPDGF-Rβ, platelet derived growth factor receptor βpHo, extracellular pHPIGF, phosphatidylinositol-glycan biosynthesis class F proteinPLCγ, phospholipase-C gammaPNS, peripheral nervous systempRCC, papillary renal cell carcinomaproteolytic cleavagePTPRζ1, receptor-type tyrosine-protein phosphatase zetaRA, rheumatoid arthritisRCC, renal cell carcinomaRD, rhabdomyosarcomaRGD, arginylglycylaspartic acidRT-PCR, real-time polymerase chain reactionSB, Southern blotSCC, squamous cell carcinomasiRNA, small interfering RNASMCs, smooth muscle cellssplicingSVZ, sub-ventricular zoneTA, tenascin assembly domaintenascin-CTGFβ, transforming growth factor βtherapeuticsTIMP, tissue inhibitor of metalloproteinasesTLR4, toll-like receptor 4TNFα, tumor necrosis factor αtranscriptionTSS, transcription start siteUBC, urothelial bladder cancerUCC, urothelial cell carcinomaVEGF, vascular endothelial growth factorVSMCs, vascular smooth muscle cellsVZ, ventricular zoneWB, immunoblot/ western blot

Identifiers

PMID25482829
PMCPMC4422809

What OpenQuestion holds

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Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.