ArticleCell reports2014
Regulatory T cells occupy an isolated niche in the intestine that is antigen independent.
Article in Cell reports, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 35 citations in OpenAlex.
- Gut microbiota in regulatory T cell generation and function: mechanisms and health implications.Gut microbes · 2025Review
- Neonatal regulatory T cells persist into adulthood across multiple tissues with high enrichment in the skin.Science advances · 2025Article
- Immunosuppressive CD29Gut · 2024Article
- A diet rich in fermentable fiber promotes robust changes in the intestinal microbiota, mitigates intestinal permeability, and attenuates autoimmune uveitis.Scientific reports · 2023Article
- Regulatory T cells as a therapeutic approach for inflammatory bowel disease.European journal of immunology · 2023Review
- Intestinal factors promoting the development of RORγtFrontiers in immunology · 2023Review
- Moving to the Outskirts: Interplay Between Regulatory T Cells and Peripheral Tissues.Frontiers in immunology · 2022Review
- Obesity and intestinal stem cell susceptibility to carcinogenesis.Nutrition & metabolism · 2021Review
- Intestinal Regulatory T Cells.Advances in experimental medicine and biology · 2021Article
- Recirculation and Residency of T Cells and Tregs: Lessons Learnt in Anacapri.Frontiers in immunology · 2020Review
- CD49b defines functionally mature Treg cells that survey skin and vascular tissues.The Journal of experimental medicine · 2018Article
- Parasitic Nematodes Exert Antimicrobial Activity and Benefit From Microbiota-Driven Support for Host Immune Regulation.Frontiers in immunology · 2018Article
- Emerging Functions of Regulatory T Cells in Tissue Homeostasis.Frontiers in immunology · 2018Review
- Functional heterogeneity of gut-resident regulatory T cells.Clinical & translational immunology · 2017Review
- CD40-signalling abrogates induction of RORγtNature communications · 2017Article
- The regulatory niche of intestinal stem cells.The Journal of physiology · 2016Review
- Development and maintenance of intestinal regulatory T cells.Nature reviews. Immunology · 2016Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
Regulatory T cells (Tregs) are CD4(+) T cells that maintain immune homeostasis and prevent autoimmunity. Like all CD4(+) T cells, Tregs require antigen-specific signals via T cell receptor-major histocompatibility complex class II (TCR-MHCII) interactions for their development. However, the requirement for MHCII in Treg homeostasis in tissues such as intestinal lamina propria (LP) is unknown. We examined LP Treg homeostasis in a transgenic mouse model that lacks peripheral TCR-MHCII interactions and generation of extrathymic Tregs (iTregs). Thymically generated Tregs entered the LP of weanlings and proliferated independently of MHCII to fill the compartment. The adult LP was a closed niche; new thymic Tregs were excluded, and Tregs in parabiotic pairs were LP resident. The isolated LP niche was interleukin-2 (IL-2) independent but dependent on commensal bacteria. Thus, an LP Treg niche can be filled, isolated, and maintained independently of antigen signals and iTregs. This niche may represent a tissue-specific mechanism for maintaining immune tolerance.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.