Evidence map›Paper›PMID 25482422›Full record

ArticlePreventive medicine2015

Quasi-causal associations of physical activity and neighborhood walkability with body mass index: a twin study.

Glen E Duncan, Stephanie Whisnant Cash, Erin E Horn, Eric Turkheimer

Abstract readTwin Study
In one paragraph

Article in Preventive medicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Review
  7. Obesity and the Built Environment: A Reappraisal.Obesity (Silver Spring, Md.) · 2020
    Review
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Glen E DuncanDepartment of Epidemiology, School of Public Health, University of Washington, Seattle, WA, United States; Nutritional Sciences Program, School of Public Health, University of Washington, Seattle, WA, United States. Electronic address: duncag@u.washington.edu.
Stephanie Whisnant CashDepartment of Epidemiology, School of Public Health, University of Washington, Seattle, WA, United States; Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA, United States.
Erin E HornDepartment of Psychology, University of Virginia, Charlottesville, VA, United States.
Eric TurkheimerDepartment of Psychology, University of Virginia, Charlottesville, VA, United States.

Funding

Building a Unique National Community Based Twin RepositoryRC2HL103416 · NHLBI · UNIVERSITY OF WASHINGTON · PI BUCHWALD, DEDRA S · 2009 to 2010
$7.7M
TWINStudy of Environment, Lifestyle Behaviors, and HealthR01AG042176 · NIA · WASHINGTON STATE UNIVERSITY · PI DUNCAN, GLEN E · 2011 to 2014
$2.2M
NHLBI NIH HHS RC2 HL103416NIA NIH HHS R01 AG042176
6 · The paper itself

Abstract

objectivePhysical activity, neighborhood walkability, and body mass index (BMI, kg/m(2)) associations were tested using quasi-experimental twin methods. We hypothesized that physical activity and walkability were independently associated with BMI within twin pairs, controlling for genetic and environmental background shared between them.

methodsData were from 6376 (64% female; 58% identical) same-sex pairs, University of Washington Twin Registry, 2008-2013. Neighborhood walking, moderate-to-vigorous physical activity (MVPA), and BMI were self-reported. Residential address was used to calculate walkability. Phenotypic (non-genetically informed) and biometric (genetically informed) regression was employed, controlling for age, sex, and race.

resultsWalking and MVPA were associated with BMI in phenotypic analyses; associations were attenuated but significant in biometric analyses (Ps<0.05). Walkability was not associated with BMI, however, was associated with walking (but not MVPA) in both phenotypic and biometric analyses (Ps<0.05), with no attenuation accounting for shared genetic and environmental background.

conclusionsThe association between activity and BMI is largely due to shared genetic and environmental factors, but a significant causal relationship remains accounting for shared background. Although walkability is not associated with BMI, it is associated with neighborhood walking (but not MVPA) accounting for shared background, suggesting a causal relationship between them.

Indexed as

Body Mass IndexEnvironment DesignResidence CharacteristicsAdultFemaleGeographic Information SystemsHumansMaleMonitoring, PhysiologicMotor ActivityMultivariate AnalysisPhenotypeTwins, DizygoticTwins, MonozygoticWalkingWashingtonBody mass indexEnvironment and public healthHeredityMotor activityTwins

Identifiers

PMID25482422
PMCPMC4274205

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.