ArticleInternational journal of cardiology2015
Osteogenic monocytes within the coronary circulation and their association with plaque vulnerability in patients with early atherosclerosis.
Article in International journal of cardiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 56 citations in OpenAlex.
- Modulation of circulating osteocalcin-expressing monocytes by glucagon like peptide-1 receptor agonists in type 2 diabetes: an exploratory pilot study.Acta diabetologica · 2026Article
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- Cellular aspects of immunity involved in the development of atherosclerosis.Frontiers in immunology · 2025Review
- Review
- Osteocalcin, Osteopontin and RUNX2 Expression in Patients' Leucocytes with Arteriosclerosis.Diseases (Basel, Switzerland) · 2021Article
- Article
- Pharmacologic epigenetic modulators of alkaline phosphatase in chronic kidney disease.Current opinion in nephrology and hypertension · 2020Review
- Calcium Signaling and Tissue Calcification.Cold Spring Harbor perspectives in biology · 2019Review
- Circulating Osteogenic Progenitor Cells in Mild, Moderate, and Severe Aortic Valve Stenosis.Mayo Clinic proceedings · 2019Article
- The Role of Monocytes and Macrophages in Human Atherosclerosis, Plaque Neoangiogenesis, and Atherothrombosis.Mediators of inflammation · 2019Review
- Human Monocyte Subsets and Phenotypes in Major Chronic Inflammatory Diseases.Frontiers in immunology · 2019Review
- Lifestyle Management of Diabetes: Implications for the Bone-Vascular Axis.Current diabetes reports · 2018Review
- High density lipoprotein modulates osteocalcin expression in circulating monocytes: a potential protective mechanism for cardiovascular disease in type 1 diabetes.Cardiovascular diabetology · 2017Article
- Intermediate CD14The international journal of cardiovascular imaging · 2017Article
- Coronary Atherosclerotic Vulnerable Plaque: Current Perspectives.Journal of the American Heart Association · 2017Review
- Osteocalcin, Vascular Calcification, and Atherosclerosis: A Systematic Review and Meta-analysis.Frontiers in endocrinology · 2017Article
- Premature Atherosclerosis and Drug Eluting Stent Restenosis in an Adult with Osteogenesis Imperfecta.The International journal of angiology : official publication of the International College of Angiology, Inc · 2016Article
- Suitable bone markers assessing bone status in patients with both coronary artery disease and diabetes.Journal of diabetes and metabolic disorders · 2015Article
- Immune system and atherosclerosis: Hostile or friendly relationship.International journal of immunopathology and pharmacologyReview
Corrections and comments
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Authors and funding
13 authors at 6 institutions in 4 countries.
Funding
Abstract
objectivesThis study tests the hypothesis that circulating mononuclear cells expressing osteocalcin (OCN) and bone alkaline phosphatase (BAP) are associated with distinct plaque tissue components in patients with early coronary atherosclerosis.
backgroundPlaque characteristics implying vulnerability develop at the earliest stage of coronary atherosclerosis. Increasing evidence indicates that cells from the myeloid lineage might serve as important mediators of destabilization. Plaque burden and its components were assessed regarding their relationship to monocytes carrying both pro-inflammatory (CD14) and osteogenic surface markers OCN and BAP.
methodsTwenty-three patients with angiographically non-obstructive coronary artery disease underwent coronary endothelial function assessment and virtual histology-intravascular ultrasound of the left coronary artery. Plaque composition was characterized in the total segment (TS) and in the target lesion (TL) containing the highest amount of plaque burden. Blood samples were collected simultaneously from the aorta and the coronary sinus. Circulating cell counts were then identified from each sample and a gradient across the coronary circulation was determined.
resultsCirculating CD14+/BAP+/OCN+ monocytes correlate with the extent of necrotic core and calcification (r=0.53, p=0.010; r=0.55, p=0.006, respectively). Importantly, coronary retention of CD14+/OCN+ cells also correlates with the amount of necrotic core and calcification (r=0.61, p=0.003; r=0.61, p=0.003) respectively.
conclusionsOur study links CD14+/BAP+/OCN+ monocytes to the pathologic remodeling of the coronary circulation and therefore associates these cells with plaque destabilization in patients with early coronary atherosclerosis.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.