ArticleScientific reports2014
Re-emergent human adenovirus genome type 7d caused an acute respiratory disease outbreak in Southern China after a twenty-one year absence.
Article in Scientific reports, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 55 papers, 2 of them syntheses that pooled it.
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Who cites it
55 citing papers in PubMed, 2 syntheses or guidelines pooled it, 83 citations in OpenAlex.
- High case fatality rate of human adenovirus type 7 infections in children: a meta-analysis and phylogenetic study of HAdV-7 epidemics over the past seven decades.Emerging microbes & infections · 2025Pooled it
- Are adenoviruses zoonotic? A systematic review of the evidence.Emerging microbes & infections · 2019Pooled it
- Adenovirus type 7d outbreak associated with severe clinical presentation, Finland, February to June 2024.Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin · 2025Article
- Protection against lethal HAdV-4 challenge in STAT1 mice by novel human monoclonal antibodies.Frontiers in immunology · 2025Article
- A prediction model for acute respiratory distress syndrome in immunocompetent adults with adenovirus-associated Pneumonia: a multicenter retrospective analysis.BMC pulmonary medicine · 2023Article
- Article
- Analysis of the typing of adenovirus and its clinical characteristics in children with acute respiratory tract infection.BMC pediatrics · 2023Article
- Current status of human adenovirus infection in China.World journal of pediatrics : WJP · 2022Review
- A Hierarchical Genotyping Framework Using DNA Melting Temperatures Applied to Adenovirus Species Typing.International journal of molecular sciences · 2022Article
- Clinical and imaging findings of patients diagnosed with adenovirus-positive pneumonia during 2015-2019 in Shanghai, China.Turkish journal of medical sciences · 2022Article
- Alterations in bile acids as metabolic signatures in the patients with human adenovirus type 7 infection.Frontiers in medicine · 2022Article
- Molecular Typing and Rapid Identification of Human Adenoviruses Associated With Respiratory Diseases Using Universal PCR and Sequencing Primers for the Three Major Capsid Genes: Penton Base, Hexon, and Fiber.Frontiers in microbiology · 2022Article
- Desmoglein 2 (DSG2) Is A Receptor of Human Adenovirus Type 55 Causing Adult Severe Community-Acquired Pneumonia.Virologica Sinica · 2021Article
- Human Adenovirus 7-Associated Hemophagocytic Lymphohistiocytosis-like Illness: Clinical and Virological Characteristics in a Cluster of Five Pediatric Cases.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2021Article
- Outbreaks of Adenovirus-associated Respiratory Illness on 5 College Campuses in the United States, 2018-2019.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2021Article
- Construction and Characterization of a Novel Recombinant Attenuated and Replication-Deficient Candidate Human Adenovirus Type 3 Vaccine: "Adenovirus Vaccine Within an Adenovirus Vector".Virologica Sinica · 2021Article
- Development and Application of a Fast Method to Acquire the Accurate Whole-Genome Sequences of Human Adenoviruses.Frontiers in microbiology · 2021Article
- Human Adenovirus Type 7 Infections in Hubei, China During 2018-2019: Epidemic Features and Genetic Characterization of the Detected Viruses.Frontiers in cellular and infection microbiology · 2021Article
- The Epidemiology, Molecular, and Clinical of Human Adenoviruses in Children Hospitalized With Acute Respiratory Infections.Frontiers in microbiology · 2021Article
- Human Adenovirus B7d-Associated Urethritis after Suspected Sexual Transmission, Japan.Emerging infectious diseases · 2020Article
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Authors and funding
17 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Human adenoviruses (HAdVs) are highly contagious pathogens causing acute respiratory disease (ARD), among other illnesses. Of the ARD genotypes, HAdV-7 presents with more severe morbidity and higher mortality than the others. We report the isolation and identification of a genome type HAdV-7d (DG01_2011) from a recent outbreak in Southern China. Genome sequencing, phylogenetic analysis, and restriction endonuclease analysis (REA) comparisons with past pathogens indicate HAdV-7d has re-emerged in Southern China after an absence of twenty-one years. Recombination analysis reveals this genome differs from the 1950s-era prototype and vaccine strains by a lateral gene transfer, substituting the coding region for the L1 52/55 kDa DNA packaging protein from HAdV-16. DG01_2011 descends from both a strain circulating in Southwestern China (2010) and a strain from Shaanxi causing a fatality and outbreak (Northwestern China; 2009). Due to the higher morbidity and mortality rates associated with HAdV-7, the surveillance, identification, and characterization of these strains in population-dense China by REA and/or whole genome sequencing are strongly indicated. With these accurate identifications of specific HAdV types and an epidemiological database of regional HAdV pathogens, along with the HAdV genome stability noted across time and space, the development, availability, and deployment of appropriate vaccines are needed.
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