ArticleJournal of the American Geriatrics Society2014
Sensory and motor peripheral nerve function and incident mobility disability.
Article in Journal of the American Geriatrics Society, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 29 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
29 citing papers in PubMed, 44 citations in OpenAlex.
- Metabolic syndrome and the benefit of a physical activity intervention on lower-extremity function: Results from a randomized clinical trial.Experimental gerontology · 2021Trial
- Effect of Metabolic Syndrome on the Mobility Benefit of a Structured Physical Activity Intervention-The Lifestyle Interventions and Independence for Elders Randomized Clinical Trial.Journal of the American Geriatrics Society · 2017Trial
- Associations Between Inflammation and Multisensory Impairment Among Older Adults.Journal of the American Geriatrics Society · 2025Article
- Whole Genome Linkage and Association Analyses Identify DLG Associated Protein-1 as a Novel Positional and Biological Candidate Gene for Muscle Strength: The Long Life Family Study.The journals of gerontology. Series A, Biological sciences and medical sciences · 2024Article
- Influence of transcutaneous electrical nerve stimulation on walking kinematics and standing balance of older adults who differ in walking speed.Experimental brain research · 2023Article
- Associations of Lower Extremity Peripheral Nerve Impairment and Risk of Dementia in Black and White Older Adults.Neurology · 2022Article
- Article
- Swallowing impairment in older adults: association with sensorimotor peripheral nerve function from the Health, Aging and Body Composition study.Aging clinical and experimental research · 2021Article
- Incident dementia and faster rates of cognitive decline are associated with worse multisensory function summary scores.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2020Article
- Peripheral Nerve Impairment and Recurrent Falls Among Women: Results From the Study of Women's Health Across the Nation.The journals of gerontology. Series A, Biological sciences and medical sciences · 2020Article
- Cardiometabolic risk factors as determinants of peripheral nerve function: the Maastricht Study.Diabetologia · 2020Article
- Association between TUG and Anthropometric Values, Vibration Perception Threshold, FHSQ and 15-D in Type 2 Diabetes Mellitus Patients.International journal of environmental research and public health · 2020Article
- Article
- Comparison between quantitative and subjective assessments of chemotherapy-induced peripheral neuropathy in cancer patients: A prospective cohort study.Physical therapy research · 2020Article
- Interrelated Neuromuscular and Clinical Risk Factors That Contribute to Falls.The journals of gerontology. Series A, Biological sciences and medical sciences · 2019Article
- Multiple Sensory Impairment Is Associated With Increased Risk of Dementia Among Black and White Older Adults.The journals of gerontology. Series A, Biological sciences and medical sciences · 2019Article
- Chronic kidney disease and peripheral nerve function in the Health, Aging and Body Composition Study.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2019Article
- Neuromuscular Attributes Associated With Lower Extremity Mobility Among Community-Dwelling Older Adults.The journals of gerontology. Series A, Biological sciences and medical sciences · 2019Article
- Motor unit activity, force steadiness, and perceived fatigability are correlated with mobility in older adults.Journal of neurophysiology · 2018Article
- Low blood pressure levels for fall injuries in older adults: the Health, Aging and Body Composition Study.European journal of ageing · 2018Article
Corrections and comments
- Erratum issued
Authors and funding
15 authors at 10 institutions in 2 countries.
Funding
Abstract
objectivesTo assess the relationship between sensorimotor nerve function and incident mobility disability over 10 years.
designProspective cohort study with longitudinal analysis.
settingTwo U.S. clinical sites.
participantsPopulation-based sample of community-dwelling older adults with no mobility disability at 2000/01 examination (N = 2,148 [Corrected]; mean age ± SD 76.5 ± 2.9, body mass index 27.1 ± 4.6; 50.2% female, 36.6% black, 10.7% with diabetes mellitus). MEASUREMENTS: Motor nerve conduction amplitude (poor <1 mV) and velocity (poor <40 m/s) were measured on the deep peroneal nerve. Sensory nerve function was measured using 10- and 1.4-g monofilaments and vibration detection threshold at the toe. Lower extremity symptoms included numbness or tingling and aching or burning pain. Incident mobility disability assessed semiannually over 8.5 years (interquartile range 4.5-9.6 years) was defined as two consecutive self-reports of a lot of difficulty or inability to walk one-quarter of a mile or climb 10 steps.
resultsNerve impairments were detected in 55% of participants, and 30% developed mobility disability. Worse motor amplitude (HR = 1.29 per SD, 95% CI = 1.16-1.44), vibration detection threshold (HR = 1.13 per SD, 95% CI = 1.04-1.23), symptoms (HR = 1.65, 95% CI = 1.26-2.17), two motor impairments (HR = 2.10, 95% CI = 1.43-3.09), two sensory impairments (HR = 1.91, 95% CI = 1.37-2.68), and three or more nerve impairments (HR = 2.33, 95% CI = 1.54-3.53) predicted incident mobility disability after adjustment. Quadriceps strength mediated relationships between certain nerve impairments and mobility disability, although most remained significant.
conclusionPoor sensorimotor nerve function independently predicted mobility disability. Future work should investigate modifiable risk factors and interventions such as strength training for preventing disability and improving function in older adults with poor nerve function.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.