Evidence map›Paper›PMID 25481764›Full record

ArticleNeuroscience letters2015

Long-term evaluation of Leber's hereditary optic neuropathy-like symptoms in rotenone administered rats.

Li Zhang, Laura Liu, Ann L Philip, Juan C Martinez, Juan C Guttierez, Mathieu Marella, Gaurav Patki, Akemi Matsuno-Yagi, Takao Yagi, Biju B Thomas

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neuroscience letters, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.3field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 3 countries.

Li ZhangEye Center, Second Affiliated Hospital, Medical School of Zhejiang University, Hangzhou, China; Ophthalmology, Keck School of Medicine, University of Southern California, Los Angeles, CA,USA.
Laura LiuDepartment of Ophthalmology, Chang Gung Memorial Hospital, Linkou Medical Center, Taoyuan, Taiwan.
Ann L PhilipOphthalmology, Keck School of Medicine, University of Southern California, Los Angeles, CA,USA.
Juan C MartinezOphthalmology, Keck School of Medicine, University of Southern California, Los Angeles, CA,USA.
Juan C GuttierezOphthalmology, Keck School of Medicine, University of Southern California, Los Angeles, CA,USA.
Mathieu MarellaMolecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA,USA.
Gaurav PatkiMolecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA,USA.
Akemi Matsuno-YagiMolecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA,USA.
Takao YagiMolecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA,USA.
Biju B ThomasOphthalmology, Keck School of Medicine, University of Southern California, Los Angeles, CA,USA. Electronic address: biju.thomas@med.usc.edu.
University of Southern California · USScripps Research Institute · USChang Gung Memorial Hospital · TW

Funding

Molecular Remedy of Mitochondrial DefectsR01EY020796 · NEI · SCRIPPS RESEARCH INSTITUTE, THE · PI YAGI, TAKAO · 2011 to 2015
$2.3M
NEI NIH HHS R01 EY020796NEI NIH HHS R01EY020796
6 · The paper itself

Abstract

Leber's hereditary optic neuropathy (LHON) is an inherited disorder affecting the retinal ganglion cells (RGCs) and their axons that lead to the loss of central vision. This study is aimed at evaluating the LHON symptoms in rats administered with rotenone microspheres into the superior colliculus (SC). Optical coherence tomography (OCT) analysis showed substantial loss of retinal nerve fiber layer (RNFL) thickness in rotenone injected rats. Optokinetic testing in rotenone treated rats showed decrease in head-tracking response. Electrophysiological mapping of the SC surface demonstrated attenuation of visually evoked responses; however, no changes were observed in the ERG data. The progressive pattern of disease manifestation in rotenone administered rats demonstrated several similarities with human disease symptoms. These rats with LHON-like symptoms can serve as a model for future investigators to design and implement reliable tests to assess the beneficial effects of therapeutic interventions for LHON disease.

Indexed as

Disease Models, AnimalRotenoneAnimalsElectroretinographyEvoked Potentials, VisualHumansMicrospheresOptic Atrophy, Hereditary, LeberRatsSuperior ColliculiTomography, Optical CoherenceRotenoneAnimal modelLeber’Rotenones hereditary optic neuropathySuperior colliculusVisual function

Identifiers

PMID25481764
PMCPMC4295626
OpenAlexW2081361438

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.