Evidence map›Paper›PMID 25481538›Full record

ArticleAccident; analysis and prevention2015

The rate ratio of injury and aggressive incident for alcohol alone, cocaine alone and simultaneous use before the event: a case-crossover study.

Jinhui Zhao, Scott Macdonald, Guilherme Borges, Chantele Joordens, Tim Stockwell, Yu Ye

Open access · greenAbstract read
In one paragraph

Article in Accident; analysis and prevention, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
1.9field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 13 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 3 countries.

Jinhui ZhaoCentre for Addictions Research of British Columbia, University of Victoria, 2300 McKenzie Ave, BC V8P 5C2 Canada. Electronic address: zhaoj@uvic.ca.
Scott MacdonaldCentre for Addictions Research of British Columbia and School of Health Information Sciences, University of Victoria, 2300 McKenzie Ave, BC V8P 5C2 Canada.
Guilherme BorgesNational Institute of Psychiatry and Metropolitan Autonomous University, Mexico City, Mexico.
Chantele JoordensCentre for Addictions Research of British Columbia, University of Victoria, 2300 McKenzie Ave, BC V8P 5C2 Canada.
Tim StockwellCentre for Addictions Research of British Columbia and Department of Psychology, University of Victoria, 2300 McKenzie Ave, BC V8P 5C2 Canada.
Yu YeAlcohol Research Group, Public Health Institute, 6475 Christie Avenue, Suite 400 Emeryville, CA 94608-1010, USA.
University of Victoria · CAPublic Health Institute · USUniversidad Autónoma Metropolitana · MX

Funding

Cross-National Analysis of Alcohol & InjuryR01AA013750 · NIAAA · PUBLIC HEALTH INSTITUTE · PI CHERPITEL, CHERYL J · 2002 to 2018
$4.4M
NIAAA NIH HHS R01 AA013750
6 · The paper itself

Abstract

objectives(i) To estimate the rate ratio (RR) of use of alcohol alone, cocaine alone, and both substances simultaneously on acute injury or an aggressive incident, (ii) to compare the RRs for simultaneous use within 3 or 6h of the event; and (iii) to compare the RRs of two measures of exposure, "hours of feeling effects" vs estimates based on self-reported quantity and frequency of use.

methodsThe study employed a case-crossover design with the frequency approach. Clients (N=616) in substance abuse treatment for alcohol or cocaine issues from 2009 to 2012 completed a self-administered questionnaire on their substance use within 3 and 6h before a recent injury or physically aggressive incident. Clients also reported detailed quantity and frequency information in relation to their typical substance use, as well as information on "feeling effects". The RR of acute harms due to substance use was estimated using the Mantel-Haenszel estimator.

resultsIn the 6-h window before the event, use of cocaine alone, alcohol alone and simultaneous alcohol and cocaine use were each significantly (P<0.05) related to a recent injury and aggressive incident. Simultaneous use was not significantly greater than use of either drug alone. Estimates of RR based on simultaneous use for a 3-h window before the event were consistently larger than those based on a 6-h window, and comparisons were significant (P<0.05) for an aggressive incident but not an injury. With reference to the two measures of exposure, three of eight comparisons of RRs were significantly larger for feeling the effects of the substance in comparison to quantity and frequency of substance use.

conclusionThese findings are consistent with increased likelihood of harms related to the acute effects of alcohol alone, cocaine alone or simultaneous use. The results are suggestive that the acute effects of these drugs may be better measured within a 3-h time window than a 6-h window. Finally, we found that "hours of feeling effects" yielded higher estimates of RR than the quantity-frequency approach; however both measures support the overall findings.

Indexed as

AggressionAccidents, TrafficAdolescentAdultAgedAged, 80 and overAlcohol DrinkingCocaine-Related DisordersComorbidityCross-Sectional StudiesDriving Under the InfluenceFemaleHumansMaleMiddle AgedSurveys and QuestionnairesAggressionAlcoholCase–crossoverCocaineInjury

Identifiers

PMID25481538
PMCPMC4314089
OpenAlexW2051029010

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.