Evidence map›Paper›PMID 25481508›Full record

ArticleEuropean child & adolescent psychiatry2015

Reduced cortical surface area in adolescents with conduct disorder.

Sagari Sarkar, Eileen Daly, Yue Feng, Christine Ecker, Michael C Craig, Duncan Harding, Quinton Deeley, Declan G M Murphy

Abstract read
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In one paragraph

Article in European child & adolescent psychiatry, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Cerebral cortex maldevelopment in syndromic craniosynostosis.Developmental medicine and child neurology · 2022
    Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Selective Mapping of Psychopathy and Externalizing to Dissociable Circuits for Inhibitory Self-Control.Clinical psychological science : a journal of the Association for Psychological Science · 2016
    Article
  10. Article
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Sagari SarkarSackler Institute for Translational Neurodevelopment, and the Department of Forensic and Neurodevelopmental Sciences, Institute of Psychiatry, King's College London, London, SE5 8AF, UK, sagari.sarkar@kcl.ac.uk.
Eileen Daly
Yue Feng
Christine Ecker
Michael C Craig
Duncan Harding
Quinton Deeley
Declan G M Murphy

Funding

Medical Research Council G0400061/69344Medical Research Council G0800298/87573
6 · The paper itself

Abstract

Children with conduct disorder (CD) are at increased risk of developing antisocial personality disorder and psychopathy in adulthood. Neuroimaging research has identified abnormal cortical volume (CV) in CD. However, CV comprises two genetically and developmentally separable components: cortical thickness (CT) and surface area (SA). Aim of this study is to explore the relationship between the cortical constituents of CV in boys with CD. We applied FreeSurfer software to structural MRI data to derive measures of CV, CT, and SA in 21 boys with CD and 19 controls. Relationships between these cortical measures were investigated. Boys with CD had significantly reduced CV and SA compared to non-CD boys in ventromedial and dorsolateral prefrontal cortex. We found no significant between-group differences in CT. Reduced prefrontal CV in boys with CD is associated with significantly reduced SA in the same regions. This finding may help to identify specific neurodevelopmental mechanisms underlying cortical deficits observed in CD.

Indexed as

AdolescentAntisocial Personality DisorderAttentionAttention Deficit Disorder with HyperactivityCase-Control StudiesChildConduct DisorderHumansMagnetic Resonance ImagingMalePrefrontal CortexSurveys and QuestionnairesYoung Adult

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.