Trial reportAddictive behaviors2015
Lifetime history of heroin use is associated with greater drug severity among prescription opioid abusers.
Trial report in Addictive behaviors, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
4 citing papers in PubMed.
- Once is too much: Early development of the opponent process in taste reactivity behavior is associated with later escalation of cocaine self-administration in rats.Brain research bulletin · 2018Article
- Heroin Use and Drug Injection among Youth Also Misusing Prescription Drugs.American journal of health behavior · 2018Article
- The costs of crime during and after publicly funded treatment for opioid use disorders: a population-level study for the state of California.Addiction (Abingdon, England) · 2017Article
- Perceived risk of heroin use among nonmedical prescription opioid users.Addictive behaviors · 2017Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
backgroundWhile research suggests primary prescription opioid (PO) abusers may exhibit less severe demographic and drug use characteristics than primary heroin abusers, less is known about whether a lifetime history of heroin use confers greater severity among PO abusers.
objectiveIn this secondary analysis, we examined demographic and drug use characteristics as a function of lifetime heroin use among 89 PO-dependent adults screened for a trial evaluating the relative efficacy of buprenorphine taper durations. Exploratory analyses also examined contribution of lifetime heroin use to treatment response among a subset of participants who received a uniform set of study procedures.
methodsBaseline characteristics were compared between participants reporting lifetime heroin use ≥5 (H(+); n=41) vs. <5 (H(-); n=48) times. Treatment response (i.e., illicit opioid abstinence and treatment retention at end of study) was examined in the subset of H(+) and H(-) participants randomized to receive the 4-week taper condition (N=22).
resultsH(+) participants were significantly older and more likely to be male. They reported longer durations of illicit opioid use, greater alcohol-related problems, more past-month cocaine use, greater lifetime IV drug use, and greater lifetime use of cigarettes, amphetamines and hallucinogens. H(+) participants also had lower scores on the Positive Symptom Distress and Depression subscales of the Brief Symptom Inventory. Finally, there was a trend toward poorer treatment outcomes among H(+) participants.
conclusionA lifetime history of heroin use may be associated with elevated drug severity and unique treatment needs among treatment-seeking PO abusers.
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