Evidence map›Paper›PMID 25481260›Full record

ReviewSeminars in radiation oncology2015

Radiation and inflammation.

Dörthe Schaue, Ewa D Micewicz, Josephine A Ratikan, Michael W Xie, Genhong Cheng, William H McBride

Abstract readReview
In one paragraph

Review in Seminars in radiation oncology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 138 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
138citing papers in PubMed, 2 pooled it
10.2field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

138 citing papers in PubMed, 2 syntheses or guidelines pooled it, 246 citations in OpenAlex.

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  16. Adverse Outcome Pathways Applied to Space Radiation Research.Environmental and molecular mutagenesis · 2025
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78 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Dörthe SchaueDepartment of Radiation Oncology, University of California at Los Angeles, Los Angeles, CA.
Ewa D MicewiczDepartment of Radiation Oncology, University of California at Los Angeles, Los Angeles, CA.
Josephine A RatikanDepartment of Radiation Oncology, University of California at Los Angeles, Los Angeles, CA.
Michael W XieDepartment of Radiation Oncology, University of California at Los Angeles, Los Angeles, CA.
Genhong ChengDepartment of Microbiology, Immunology & Molecular Genetics, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, CA.
William H McBrideDepartment of Radiation Oncology, University of California at Los Angeles, Los Angeles, CA. Electronic address: wmcbride@mednet.ucla.edu.
University of California, Los Angeles · US

Funding

UCLA Center for Biological RadioprotectorsU19AI067769 · NIAID · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI MCBRIDE, WILLIAM H. · 2005 to 2019
$44.6M
NIAID NIH HHS U19 AI067769NIAID NIH HHS U19 AI067769/NIAID
6 · The paper itself

Abstract

The immune system has the power to modulate the expression of radiation-induced normal and tumor tissue damage. On the one hand, it can contribute to cancer cure, and on the other hand, it can influence acute and late radiation side effects, which in many ways resemble acute and chronic inflammatory disease states. The way radiation-induced inflammation feeds into adaptive antigen-specific immune responses adds another dimension to the tumor-host cross talk during radiation therapy and to possible radiation-driven autoimmune responses. Understanding how radiation affects inflammation and immunity is therefore critical if we are to effectively manipulate these forces for benefit in radiation oncology treatments.

Indexed as

HumansImmune SystemInflammationNeoplasmsRadiation Injuries

Identifiers

PMID25481260
PMCPMC4378687
OpenAlexW2004240996

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.