Evidence map›Paper›PMID 25481035›Full record

ReviewScience China. Life sciences2015

Open Sesame: treasure in store-operated calcium entry pathway for cancer therapy.

Zui Pan, JianJie Ma

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Science China. Life sciences, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
  4. Article
  5. Article
  6. Article
  7. Review
  8. Article
  9. Review
  10. Article
  11. Article
  12. Article
  13. Article
  14. MnMethods in molecular biology (Clifton, N.J.) · 2018
    Article
  15. Targeting calcium signaling in cancer therapy.Acta pharmaceutica Sinica. B · 2017
    Review
  16. Review
  17. Review
  18. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Zui PanDepartment of Internal Medicine, The Ohio State University Wexner Medical Center, Columbus, OH, 43210, USA, Zui.Pan@osumc.edu.
JianJie Ma

Funding

Ca Sparks in Muscle Aging and DystrophyR01AG028614 · NIA · UNIV OF MED/DENT NJ-R W JOHNSON MED SCH · PI MA, JIANJIE · 2006 to 2016
$4.1M
NIA NIH HHS R01 AG028614
6 · The paper itself

Abstract

Store-operated Ca(2+) entry (SOCE) controls intracellular Ca(2+) homeostasis and regulates a wide range of cellular events including proliferation, migration and invasion. The discovery of STIM proteins as Ca(2+) sensors and Orai proteins as Ca(2+) channel pore forming units provided molecular tools to understand the physiological function of SOCE. Many studies have revealed the pathophysiological roles of Orai and STIM in tumor cells. This review focuses on recent advances in SOCE and its contribution to tumorigenesis. Altered Orai and/or STIM functions may serve as biomarkers for cancer prognosis, and targeting the SOCE pathway may provide a novel means for cancer treatment.

Indexed as

Ion TransportCalciumCalcium SignalingHumansNeoplasmsPrognosisCalcium

Identifiers

PMID25481035
PMCPMC4765918

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.