ArticlePediatric nephrology (Berlin, Germany)2015
Comparison between adults and children with Henoch-Schönlein purpura nephritis.
Article in Pediatric nephrology (Berlin, Germany), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 2 of them syntheses that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
24 citing papers in PubMed, 2 syntheses or guidelines pooled it, 40 citations in OpenAlex.
- Predictability of the Oxford classification of IgA nephropathy in Henoch-Schonlein purpura nephritis.International urology and nephrology · 2022Pooled it
- The efficacy and safety of immunosuppressive agents plus steroids compared with steroids alone in the treatment of Henoch-Schönlein purpura nephritis: A meta-analysis.International urology and nephrology · 2019Pooled it
- Clinical, laboratory, and pathological correlates of crescent formation in biopsy-proven pediatric IgA vasculitis nephritis.Pediatric nephrology (Berlin, Germany) · 2026Article
- Diagnostic value of hematological inflammatory indices for renal involvement in adult IgA vasculitis: A cross-sectional study.Medicine · 2026Article
- Disease Course and Long-Term Outcomes in Adult IgA Vasculitis Nephritis: A Prospective Observational Study.Diagnostics (Basel, Switzerland) · 2025Article
- Efficacy and Long-Term Outcomes of Tacrolimus versus Cyclophosphamide and Mycophenolate Mofetil in the Management of Pediatric IgA Vasculitis Nephritis: A Cohort Study in Single-Center.Drug design, development and therapy · 2025Article
- Overview of childhood vasculitis.Journal of rheumatic diseases · 2024Review
- [Immunoglobulin A vasculitis].Innere Medizin (Heidelberg, Germany) · 2024Review
- Worldwide Distribution and Extracutaneous Manifestations of Henoch-Schönlein Purpura in Adults: Narrative Review.JMIR dermatology · 2024Review
- Does age at disease onset affect the clinical presentation and outcome in children with immunoglobulin A vasculitis?Archives of rheumatology · 2023Article
- Bowman's capsule rupture and the Oxford MEST-C score in adult patients with Immunoglobulin a vasculitis nephritis: a single center experience.Annals of medicine · 2023Article
- [Update on immunoglobulin A vasculitis].Zeitschrift fur Rheumatologie · 2022Review
- Imbalanced Th17/Treg in peripheral blood of adult patients with immunoglobulin A vasculitis nephritis.Central-European journal of immunology · 2021Article
- Global Glomerulosclerosis and Segmental Glomerulosclerosis Could Serve as Effective Markers for Prognosis and Treatment of IgA Vasculitis With Nephritis.Frontiers in medicine · 2020Article
- Role of p300 in the pathogenesis of Henoch-Schonlein purpura nephritis and as a new target of glucocorticoid therapy in mice.Chinese medical journal · 2019Article
- Different histological classifications for Henoch-Schönlein purpura nephritis: which one should be used?Pediatric rheumatology online journal · 2019Review
- Insight into inflammatory cell and cytokine profiles in adult IgA vasculitis.Clinical rheumatology · 2019Article
- Significance of histological crescent formation in patients with IgA vasculitis (Henoch-Schönlein purpura)-related nephritis: a cohort in the adult Chinese population.BMC nephrology · 2018Article
- Clinical Characteristics and Treatment Patterns of Children and Adults With IgA Nephropathy or IgA Vasculitis: Findings From the CureGN Study.Kidney international reports · 2018Article
- Adult Onset Henoch-Schonlein Purpura associated with a Metastatic Malignancy of Unknown Primary Origin.Hawai'i journal of medicine & public health : a journal of Asia Pacific Medicine & Public Health · 2018Article
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundHenoch-Schönlein purpura (HSP) mainly affects children, but age is also thought to be an important prognostic factor. Kidney involvement is a major cause of mortality in HSP patients. The purpose of this study was to analyze the clinicopathological correlations between adults and children.
methodsA total of 208 children and 75 adult patients with HSP nephritis (HSPN) were evaluated. All patients underwent a renal biopsy.
resultsExtra-renal symptoms (arthritis and abdominal pain) were more common in the pediatric patient group than in the adult group (P < 0.05), but renal symptoms (edema and hypertension) were relatively rare (P < 0.05). A significant positive correlation was noted between pathological type and clinical type (P < 0.01). Pathological activity was positively related to renal failure, abdominal pain, microscopic hematuria, hypertension, and proteinuria (P < 0.05). Pathological chronicity was positively associated with age, duration of follow-up since the onset of palpable purpura, renal failure, lower extremity edema, hypertension, and proteinuria (P < 0.05).
conclusionsVarious clinicopathological differences exist between children and adults with HSPN. Massive proteinuria, renal failure, and abdominal pain usually correlated with severe pathology. Renal biopsy should be performed in both pediatric and adult HSPN patients with repeated hematuria and/or consistent minimal proteinuria.
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