ArticleEukaryotic cell2015
Asexual propagation of a virulent clone complex in a human and feline outbreak of sporotrichosis.
Article in Eukaryotic cell, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed, 56 citations in OpenAlex.
- Susceptibility Profiles Among Sporothrix brasiliensis Genotypes in the Ongoing Zoonotic Sporotrichosis Epidemic in Brazil, Argentina and Paraguay.Mycopathologia · 2026Article
- Genome variation of Sporothrix schenckii and Sporothrix brasiliensis.PLoS neglected tropical diseases · 2026Article
- Cat-transmitted Sporotrichosis: A Clonal Household Outbreak with Atypical Human and Canine Disease Due to Sporothrix brasiliensis.Mycopathologia · 2026Article
- Sporothrix is neglected among the neglected.PLoS pathogens · 2025Article
- Analyses of the Genetic Diversity and Population Structures ofJournal of fungi (Basel, Switzerland) · 2024Article
- Emerging Cases of Cat-Transmitted Sporotrichosis Driven by Sporothrix brasiliensis in Northeast Brazil.Mycopathologia · 2024Article
- Multifocal Sporotrichosis Associated with Armadillo Hunting in Midwest Brazil: An In-Depth Case Study and Comprehensive Literature Analysis.Mycopathologia · 2024Review
- In vitro activity of the anthelmintic drug niclosamide against Sporothrix spp. strains with distinct genetic and antifungal susceptibility backgrounds.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2024Article
- Emergence of zoonotic sporotrichosis in Brazil: a genomic epidemiology study.The Lancet. Microbe · 2024Article
- Structure of the Mating-Type Genes and Mating Systems ofJournal of fungi (Basel, Switzerland) · 2023Article
- The Mating Type (MAT) and Virulence ofMicroorganisms · 2023Article
- Human and Feline Sporotrichosis in a Reference Center of Southeastern Brazil: Genetic Differentiation, Diversity, and Antifungal Susceptibility ofJournal of fungi (Basel, Switzerland) · 2023Article
- High-Throughput Microsatellite Markers Development for Genetic Characterization of EmergingJournal of fungi (Basel, Switzerland) · 2023Article
- Trends in Molecular Diagnostics and Genotyping Tools Applied for EmergingJournal of fungi (Basel, Switzerland) · 2022Review
- Current Progress on Epidemiology, Diagnosis, and Treatment of Sporotrichosis and Their Future Trends.Journal of fungi (Basel, Switzerland) · 2022Review
- Cell compensatory responses of fungi to damage of the cell wall induced by Calcofluor White and Congo Red with emphasis onFrontiers in cellular and infection microbiology · 2022Review
- Exploring genetic diversity, population structure, and phylogeography inStudies in mycology · 2021Article
- Trends in the molecular epidemiology and population genetics of emergingStudies in mycology · 2021Article
- Evolution of virulence-related phenotypes of Sporothrix brasiliensis isolates from patients with chronic sporotrichosis and acquired immunodeficiency syndrome.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2021Article
- A novelEmerging microbes & infections · 2020Article
Corrections and comments
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Authors and funding
14 authors at 7 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Sporotrichosis is one of the most frequent subcutaneous fungal infections in humans and animals caused by members of the plant-associated, dimorphic genus Sporothrix. Three of the four medically important Sporothrix species found in Brazil have been considered asexual as no sexual stage has ever been reported in Sporothrix schenckii, Sporothrix brasiliensis, or Sporothrix globosa. We have identified the mating type (MAT) loci in the S. schenckii (strain 1099-18/ATCC MYA-4821) and S. brasiliensis (strain 5110/ATCC MYA-4823) genomes by using comparative genomic approaches to determine the mating type ratio in these pathogen populations. Our analysis revealed the presence of a MAT1-1 locus in S. schenckii while a MAT1-2 locus was found in S. brasiliensis representing genomic synteny to other Sordariomycetes. Furthermore, the components of the mitogen-activated protein kinase (MAPK)-pheromone pathway, pheromone processing enzymes, and meiotic regulators have also been identified in the two pathogens, suggesting the potential for sexual reproduction. The ratio of MAT1-1 to MAT1-2 was not significantly different from 1:1 for all three Sporothrix species, but the population of S. brasiliensis in the outbreaks originated from a single mating type. We also explored the population genetic structure of these pathogens using sequence data of two loci to improve our knowledge of the pattern of geographic distribution, genetic variation, and virulence phenotypes. Population genetics data showed significant population differentiation and clonality with a low level of haplotype diversity in S. brasiliensis isolates from different regions of sporotrichosis outbreaks in Brazil. In contrast, S. schenckii isolates demonstrated a high degree of genetic variability without significant geographic differentiation, indicating the presence of recombination. This study demonstrated that two species causing the same disease have contrasting reproductive strategies and genetic variability patterns.
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