ArticleDevelopment (Cambridge, England)2015
Coordinate control of terminal dendrite patterning and dynamics by the membrane protein Raw.
Article in Development (Cambridge, England), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
16 citing papers in PubMed, 27 citations in OpenAlex.
- Dendrite intercalation between epidermal cells tunes nociceptor sensitivity to mechanical stimuli in Drosophila larvae.PLoS genetics · 2024Article
- Dendrite intercalation between epidermal cells tunes nociceptor sensitivity to mechanical stimuli inbioRxiv : the preprint server for biology · 2023Article
- Opposing roles of Fos, Raw, and SARM1 in the regulation of axonal degeneration and synaptic structure.Frontiers in cellular neuroscience · 2023Article
- Transparent Touch: Insights From Model Systems on Epidermal Control of Somatosensory Innervation.Frontiers in cellular neuroscience · 2021Review
- An Efficient Screen for Cell-Intrinsic Factors Identifies the Chaperonin CCT and Multiple Conserved Mechanisms as Mediating Dendrite Morphogenesis.Frontiers in cellular neuroscience · 2020Article
- Degeneration of Injured Axons and Dendrites Requires Restraint of a Protective JNK Signaling Pathway by the Transmembrane Protein Raw.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2019Article
- Review
- RNA Interference (RNAi) Screening inGenetics · 2018Article
- Identification of raw as a regulator of glial development.PloS one · 2018Article
- Effects of mutating α-tubulin lysine 40 on sensory dendrite development.Journal of cell science · 2017Article
- ATF3 acts as a rheostat to control JNK signalling during intestinal regeneration.Nature communications · 2017Article
- Wiring dendrites in layers and columns.Journal of neurogenetics · 2016Review
- Article
- Regulation of dendrite growth and maintenance by exocytosis.Journal of cell science · 2015Article
- RORα Regulates Multiple Aspects of Dendrite Development in Cerebellar Purkinje Cells In Vivo.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
- The SLC36 transporter Pathetic is required for extreme dendrite growth in Drosophila sensory neurons.Genes & development · 2015Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
The directional flow of information in neurons depends on compartmentalization: dendrites receive inputs whereas axons transmit them. Axons and dendrites likewise contain structurally and functionally distinct subcompartments. Axon/dendrite compartmentalization can be attributed to neuronal polarization, but the developmental origin of subcompartments in axons and dendrites is less well understood. To identify the developmental bases for compartment-specific patterning in dendrites, we screened for mutations that affect discrete dendritic domains in Drosophila sensory neurons. From this screen, we identified mutations that affected distinct aspects of terminal dendrite development with little or no effect on major dendrite patterning. Mutation of one gene, raw, affected multiple aspects of terminal dendrite patterning, suggesting that Raw might coordinate multiple signaling pathways to shape terminal dendrite growth. Consistent with this notion, Raw localizes to branch-points and promotes dendrite stabilization together with the Tricornered (Trc) kinase via effects on cell adhesion. Raw independently influences terminal dendrite elongation through a mechanism that involves modulation of the cytoskeleton, and this pathway is likely to involve the RNA-binding protein Argonaute 1 (AGO1), as raw and AGO1 genetically interact to promote terminal dendrite growth but not adhesion. Thus, Raw defines a potential point of convergence in distinct pathways shaping terminal dendrite patterning.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.