ArticleGenome biology and evolution2014
Constraint and adaptation in newt toll-like receptor genes.
Article in Genome biology and evolution, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 47 citations in OpenAlex.
- Positive Selection on Mammalian Immune Genes-Effects of Gene Function and Selective Constraint.Molecular biology and evolution · 2025Article
- Genome-wide identification and characterisation of Toll-like receptors in Chinese spiny frog (Frontiers in genetics · 2025Article
- Positive Selection of TLR2 and MyD88 Genes Provides Insights Into the Molecular Basis of Immunological Adaptation in Amphibians.Ecology and evolution · 2024Article
- Ancient fish lineages illuminate toll-like receptor diversification in early vertebrate evolution.Immunogenetics · 2023Article
- The characterization of toll-like receptor repertoire inEcology and evolution · 2023Article
- The amphibian immune system.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2023Review
- Cytokine gene polymorphism and parasite susceptibility in free-living rodents: Importance of non-coding variants.PloS one · 2023Article
- Distinct toll-like receptor signaling in the salamander response to tissue damage.Developmental dynamics : an official publication of the American Association of Anatomists · 2022Article
- Genetic drift and bottleneck do not influence diversity in Toll-like receptor genes at a small spatial scale in a Himalayan passerine.Ecology and evolution · 2020Article
- Article
- The Genome of the Great Gerbil Reveals Species-Specific Duplication of an MHCII Gene.Genome biology and evolution · 2020Article
- Evolutionary History of the Toll-Like Receptor Gene Family across Vertebrates.Genome biology and evolution · 2020Article
- Profilin choreographs actin and microtubules in cells and cancer.International review of cell and molecular biology · 2020Article
- Signatures of balancing selection in toll-like receptor (TLRs) genes - novel insights from a free-living rodent.Scientific reports · 2018Article
- Article
- Selective Landscapes in newt Immune Genes Inferred from Patterns of Nucleotide Variation.Genome biology and evolution · 2016Article
- Adaptive evolution of virus-sensing toll-like receptor 8 in bats.Immunogenetics · 2016Article
- Changes in selective pressures associated with human population expansion may explain metabolic and immune related pathways enriched for signatures of positive selection.BMC genomics · 2016Article
- Reptile Toll-like receptor 5 unveils adaptive evolution of bacterial flagellin recognition.Scientific reports · 2016Article
- Hsp90 regulates autophagy and plays a role in cancer therapy.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2016Review
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Acute die-offs of amphibian populations worldwide have been linked to the emergence of viral and fungal diseases. Inter and intraspecific immunogenetic differences may influence the outcome of infection. Toll-like receptors (TLRs) are an essential component of innate immunity and also prime acquired defenses. We report the first comprehensive assessment of TLR gene variation for urodele amphibians. The Lissotriton newt TLR repertoire includes representatives of 13 families and is compositionally most similar to that of the anuran Xenopus. Both ancient and recent gene duplications have occurred in urodeles, bringing the total number of TLR genes to at least 21. Purifying selection has predominated the evolution of newt TLRs in both long (∼70 Ma) and medium (∼18 Ma) timescales. However, we find evidence for both purifying and positive selection acting on TLRs in two recently diverged (2-5 Ma) allopatric evolutionary lineages (Lissotriton montandoni and L. vulgaris graecus). Overall, both forms of selection have been stronger in L. v. graecus, while constraint on most TLR genes in L. montandoni appears relaxed. The differences in selection regimes are unlikely to be biased by demographic effects because these were controlled by means of a historical demographic model derived from an independent data set of 62 loci. We infer that TLR genes undergo distinct trajectories of adaptive evolution in closely related amphibian lineages, highlight the potential of TLRs to capture the signatures of different assemblages of pathogenic microorganisms, and suggest differences between lineages in the relative roles of innate and acquired immunity.
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