Evidence map›Paper›PMID 25480638›Full record

ReviewAdvances in experimental medicine and biology2014

Systems biology of platelet-vessel wall interactions.

Yolande Chen, Seth Joel Corey, Oleg V Kim, Mark S Alber

Open access · greenAbstract readReview
In one paragraph

Review in Advances in experimental medicine and biology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.5field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 5 citations in OpenAlex.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 4 institutions in 1 country.

Yolande ChenRH Lurie Comprehensive Cancer Center, Northwestern University Feinberg School of Medicine, Rm 5-220, 303 E. Superior St., 60611, Chicago, IL, USA, yolande-chen@northwestern.edu.
Seth Joel Corey
Oleg V Kim
Mark S Alber
Indiana University School of MedicineLurie Children's Hospital · USNorthwestern University · USUniversity of Notre Dame · US

Funding

Multiscale Modeling of Myelodysplastic SyndromesR01HL128173 · NHLBI · VIRGINIA COMMONWEALTH UNIVERSITY · PI COREY, SETH JOEL, KIMMEL, MAREK · 2015 to 2019
$3.8M
Multiscale modeling and empirical study of a mechanism limiting blood clot growthU01HL116330 · NHLBI · UNIVERSITY OF NOTRE DAME · PI ALBER, MARK · 2014 to 2018
$3.5M
Scaffolding Proteins in Macrophage PhagocytosisR01HL080052 · NHLBI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI COREY, SETH JOEL · 2005 to 2008
$1.3M
The F-BAR protein CIP4 in WAS-dependent thrombocytopeniaR21HL106462 · NHLBI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI COREY, SETH JOEL · 2011 to 2012
$444k
NHLBI NIH HHS R01 HL080052NHLBI NIH HHS R01 HL128173NHLBI NIH HHS R21 HL106462NHLBI NIH HHS R21HL106462NHLBI NIH HHS U01 HL116330NHLBI NIH HHS U01HL116330
6 · The paper itself

Abstract

Platelets are small, anucleated cells that participate in primary hemostasis by forming a hemostatic plug at the site of a blood vessel's breach, preventing blood loss. However, hemostatic events can lead to excessive thrombosis, resulting in life-threatening strokes, emboli, or infarction. Development of multi-scale models coupling processes at several scales and running predictive model simulations on powerful computer clusters can help interdisciplinary groups of researchers to suggest and test new patient-specific treatment strategies.

Indexed as

Cell CommunicationSystems BiologyAnimalsBlood CoagulationBlood PlateletsBlood VesselsHemostasisHumansPlatelet ActivationPlatelet Adhesiveness

Identifiers

PMID25480638
PMCPMC5338572
OpenAlexW2184255072

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.