ArticleMalaria journal2014
Natural variation in virulence of the entomopathogenic fungus Beauveria bassiana against malaria mosquitoes.
Article in Malaria journal, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.
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23 citing papers in PubMed, 1 synthesis or guideline pooled it, 63 citations in OpenAlex.
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- Entomopathogenic Fungi as a Potential Management Tool for the Control of Urban Malaria Vector,Journal of fungi (Basel, Switzerland) · 2023Article
- A Sensitive Method for DetectingThe Canadian journal of infectious diseases & medical microbiology = Journal canadien des maladies infectieuses et de la microbiologie medicale · 2023Article
- Malaria-Transmitting Vectors Microbiota: Overview and Interactions WithFrontiers in microbiology · 2022Review
- Development ofFrontiers in microbiology · 2022Article
- Entomopathogenic fungi as the microbial frontline against the alien Eucalyptus pest Gonipterus platensis in Brazil.Scientific reports · 2021Article
- Infection of the Stable Fly,Frontiers in fungal biology · 2021Article
- Secretomic analysis of Beauveria bassiana related to cattle tick, Rhipicephalus microplus, infection.Folia microbiologica · 2019Article
- The interplay between dose and immune system activation determines fungal infection outcome in the African malaria mosquito, Anopheles gambiae.Developmental and comparative immunology · 2018Article
- Variation in physiological host range in three strains of two species of the entomopathogenic fungus Beauveria.PloS one · 2018Article
- Experimental evolution to increase the efficacy of the entomopathogenic fungusEvolutionary applications · 2017Article
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundInsecticide resistance is greatly hampering current efforts to control malaria and therefore alternative methods are needed. Entomopathogenic fungi have been proposed as an alternative with a special focus on the cosmopolitan species Beauveria bassiana. However, few studies have analysed the effects of natural variation within fungal isolates on mosquito survival, and the implications and possible exploitation for malaria control.
methodsLaboratory bioassays were performed on adult female mosquitoes (Anopheles coluzzii) with spores from 29 isolates of B. bassiana, originating from different parts of the world. In addition, phenotypic characteristics of the fungal isolates such as sporulation, spore size and growth rate were studied to explore their relationship with virulence.
resultsAll tested isolates of B. bassiana killed An. coluzzii mosquitoes, and the rate at which this happened differed significantly among the isolates. The risk of mosquitoes dying was around ten times higher when they were exposed to the most virulent as compared to the least virulent isolate. There was significant variation among isolates in spore size, growth rate and sporulation, but none of these morphological characteristics were correlated, and thus predictive, for the ability of the fungal isolate to kill malaria mosquitoes.
conclusionsThis study shows that there is a wide natural variation in virulence of isolates of B. bassiana, and that selecting an appropriate fungal isolate is highly relevant in killing and thus controlling malaria mosquitoes, particularly if used as part of an integrated vector management strategy. Also, the wide variation observed in virulence offers the opportunity to better understand the molecular and genetic mechanisms that drive this variation and thus to address the potential development of resistance against entomopathogenic fungi.
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