ArticleHaematologica2015
The 7p15.3 (rs4487645) association for multiple myeloma shows strong allele-specific regulation of the MYC-interacting gene CDCA7L in malignant plasma cells.
Open access · goldAbstract readLetter
In one paragraph
Article in Haematologica, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 7 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed, 7 pooled it
1.5field-weighted citation impact, top 17% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 7 syntheses or guidelines pooled it, 33 citations in OpenAlex.
- GWAS-Identified Variants for Obesity Do Not Influence the Risk of Developing Multiple Myeloma: A Population-Based Study and Meta-Analysis.International journal of molecular sciences · 2023Pooled it
- Genome-wide meta-analysis of monoclonal gammopathy of undetermined significance (MGUS) identifies risk loci impacting IRF-6.Blood cancer journal · 2022Pooled it
- A meta-analysis of genome-wide association studies of multiple myeloma among men and women of African ancestry.Blood advances · 2020Pooled it
- Transcriptome-wide association study of multiple myeloma identifies candidate susceptibility genes.Human genomics · 2019Pooled it
- A Meta-analysis of Multiple Myeloma Risk Regions in African and European Ancestry Populations Identifies Putatively Functional Loci.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2016Pooled it
- Pooled it
- Genome-wide association study identifies variation at 6q25.1 associated with survival in multiple myeloma.Nature communications · 2016Pooled it
- Genetic architecture of multiple myeloma: From somatic alterations to germline susceptibility and clinical implications.Translational oncology · 2026Review
- Sequence variants influencing the regulation of serum IgG subclass levels.Nature communications · 2024Article
- Deciphering the genetics and mechanisms of predisposition to multiple myeloma.Nature communications · 2024Article
- Resolving the spatial architecture of myeloma and its microenvironment at the single-cell level.Nature communications · 2023Article
- Current perspectives on interethnic variability in multiple myeloma: Single cell technology, population pharmacogenetics and molecular signal transduction.Translational oncology · 2022Article
- Epidemiology, genetics and treatment of multiple myeloma and precursor diseases.International journal of cancer · 2021Review
- Review
- Immunomagnetic B cell isolation as a tool to study blood cell subsets and enrich B cell transcripts.BMC research notes · 2021Article
- Genetic predisposition for multiple myeloma.Leukemia · 2020Review
- Germline Risk Contribution to Genomic Instability in Multiple Myeloma.Frontiers in genetics · 2019Review
- Genome-wide interaction and pathway-based identification of key regulators in multiple myeloma.Communications biology · 2019Article
- Germline Lysine-Specific Demethylase 1 (Cancer research · 2018Article
- The multiple myeloma risk allele at 5q15 lowers ELL2 expression and increases ribosomal gene expression.Nature communications · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
24 authors at 11 institutions in 6 countries.
Niels WeinholdDepartment of Internal Medicine V, University of Heidelberg, Germany.
Tobias MeissnerDepartment of Internal Medicine V, University of Heidelberg, Germany Department of Molecular & Experimental Medicine, The Scripps Research Institute, La Jolla, CA, USA.
David C JohnsonCentre for Myeloma Research, Division of Molecular Pathology, Institute of Cancer Research, Sutton, Surrey, SM2 5NG, UK.
Anja SeckingerDepartment of Internal Medicine V, University of Heidelberg, Germany.
Jérôme MoreauxINSERM, Unité 1040, Institut de Recherche en Biothérapie, Centre Hospitalier Universitaire de Montpellier, Hôpital Saint Eloi, Avenue Augustin Fliche, 34295 Montpellier, France.
Asta FörstiGerman Cancer Research Center, Heidelberg, Germany Center for Primary Health Care Research, Lund University, Malmo, Sweden.
Bowang ChenGerman Cancer Research Center, Heidelberg, Germany.
Jolanta NickelDepartment of Internal Medicine V, University of Heidelberg, Germany.
Daniel ChubbMolecular and Population Genetics, Division of Genetics and Epidemiology, Institute of Cancer Research, Sutton, Surrey, UK.
Andrew C RawstronHaematological Malignancy Diagnostic Service Laboratory, St James University Hospital, Leeds, UK.
Chi DoughtyHaematological Malignancy Diagnostic Service Laboratory, St James University Hospital, Leeds, UK.
Nasrin B DahirCentre for Myeloma Research, Division of Molecular Pathology, Institute of Cancer Research, Sutton, Surrey, SM2 5NG, UK.
Dil B BegumCentre for Myeloma Research, Division of Molecular Pathology, Institute of Cancer Research, Sutton, Surrey, SM2 5NG, UK.
Kwee YoungDepartment of Haematology, University College London Hospital, UK.
Brian A WalkerCentre for Myeloma Research, Division of Molecular Pathology, Institute of Cancer Research, Sutton, Surrey, SM2 5NG, UK.
Per HoffmannInstitute of Human Genetics, University of Bonn, Germany Division of Medical Genetics, Department of Biomedicine, University of Basel, Switzerland.
Marcus M NöthenInstitute of Human Genetics, University of Bonn, Germany Department of Genomics, Life & Brain Center, University of Bonn, Germany.
Faith E DaviesCentre for Myeloma Research, Division of Molecular Pathology, Institute of Cancer Research, Sutton, Surrey, SM2 5NG, UK.
Bernard KleinINSERM, Unité 1040, Institut de Recherche en Biothérapie, Centre Hospitalier Universitaire de Montpellier, Hôpital Saint Eloi, Avenue Augustin Fliche, 34295 Montpellier, France.
Hartmut GoldschmidtDepartment of Internal Medicine V, University of Heidelberg, Germany National Centre for Tumor Diseases, Heidelberg, Germany.
Gareth J MorganCentre for Myeloma Research, Division of Molecular Pathology, Institute of Cancer Research, Sutton, Surrey, SM2 5NG, UK.
Richard S HoulstonMolecular and Population Genetics, Division of Genetics and Epidemiology, Institute of Cancer Research, Sutton, Surrey, UK.
Dirk HoseDepartment of Internal Medicine V, University of Heidelberg, Germany National Centre for Tumor Diseases, Heidelberg, Germany dirk.hose@med.uni-heidelberg.de.
Kari HemminkiGerman Cancer Research Center, Heidelberg, Germany Center for Primary Health Care Research, Lund University, Malmo, Sweden.
Institute of Cancer Research · GBHeidelberg University · DENational Center for Tumor Diseases · DESt James's University Hospital · GBCentre Hospitalier Universitaire de Montpellier · FRGerman Cancer Research Center · DEInserm · FRScripps Research Institute · USUniversity College London · GBUniversity of Basel · CHUniversity of Bonn · DE
Funding
No grant is acknowledged in the PubMed record.
Abstract
PubMed holds no abstract for this paper.
Indexed as
Chromosomes, Human, Pair 7Gene Expression Regulation, NeoplasticAgedAllelesBinding SitesChromosome MappingFemaleHumansInterferon Regulatory Factor-4Interferon Regulatory FactorsMaleMiddle AgedMultiple MyelomaPlasma CellsPolymorphism, Single NucleotideProtein BindingCDCA7L protein, humanInterferon Regulatory Factor-4Interferon Regulatory FactorsMYC protein, humanProto-Oncogene Proteins c-mycRepressor ProteinseQTLmultiple myelomarisksingle nucleotide polymorphism
Identifiers
What OpenQuestion holds
Textmetadata
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.