Evidence map›Paper›PMID 25480404›Full record

ReviewDigestive diseases and sciences2015

Gastrin May Mediate the Carcinogenic Effect of Helicobacter pylori Infection of the Stomach.

Helge L Waldum, Øyvind Hauso, Øystein F Sørdal, Reidar Fossmark

Abstract readReview
PubMed Publisher
In one paragraph

Review in Digestive diseases and sciences, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed
3.5field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 46 citations in OpenAlex.

  1. Review
  2. Article
  3. Inflammation and Digestive Cancer.International journal of molecular sciences · 2023
    Review
  4. Review
  5. Review
  6. Article
  7. Review
  8. Review
  9. Gastritis, Gastric Polyps and Gastric Cancer.International journal of molecular sciences · 2021
    Review
  10. Article
  11. Review
  12. Review
  13. Article
  14. Role of Autoimmune Gastritis in Gastric Cancer.Clinical and translational gastroenterology · 2019
    Article
  15. Review
  16. Proton pump inhibitor: The dual role in gastric cancer.World journal of gastroenterology · 2019
    Review
  17. The Reduction in Gastric Atrophy afterInternational journal of molecular sciences · 2019
    Article
  18. Types of Gastric Carcinomas.International journal of molecular sciences · 2018
    Review
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Helge L WaldumDepartment of Cancer Research and Molecular Medicine, Faculty of Medicine, Norwegian University of Science and Technology, Prinsesse Kristinas Gate 1, 7006, Trondheim, Norway, helge.waldum@ntnu.no.
Øyvind Hauso
Øystein F Sørdal
Reidar Fossmark
Norwegian University of Science and Technology · NO

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Gastric cancer occurs almost exclusively in patients with gastritis. Since Helicobacter pylori (Hp) was proved to cause gastritis, Hp was also expected to play a role in gastric carcinogenesis. Despite extensive studies, the mechanisms by which Hp cause gastric cancer are still poorly understood. However, there is evidence that the anatomical site of Hp infection is of major importance. Infection confined to the antral mucosa protects against gastric cancer but predisposes to duodenal ulcer, whereas Hp infection of the oxyntic mucosa increases the risk of gastric cancer. Hp infection does not predispose to cancers in the gastric cardia. In patients with atrophic gastritis of the oxyntic mucosa, the intragastric pH is elevated and the concentration of microorganisms in the stomach is increased. This does not lead to increased risk of gastric cancer at all anatomical sites. The site specificity of Hp infection in relation to cancer risk indicates that neither Hp nor the changes in gastric microflora due to gastric hypoacidity are carcinogenic per se. However, reduced gastric acidity also leads to hypergastrinemia, which stimulates the function and proliferation of enterochromaffin-like (ECL) cells located in the oxyntic mucosa. The ECL cell may be more important in human gastric carcinogenesis than previously realized, as every condition causing long-term hypergastrinemia in animals results in the development of neoplasia in the oxyntic mucosa. Patients with hypergastrinemia will far more often develop carcinomas in the gastric corpus. In conclusion, hypergastrinemia may explain the carcinogenic effect of Hp.

Indexed as

AnimalsGastric MucosaGastrinsGastritisHelicobacter InfectionsHelicobacter pyloriHumansHydrogen-Ion ConcentrationRiskStomach NeoplasmsGastrins

Identifiers

PMID25480404
OpenAlexW1966763940

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.