Evidence map›Paper›PMID 25480324›Full record

ReviewScience China. Life sciences2015

Canonical transient receptor potential 4 and its small molecule modulators.

Jie Fu, ZhaoBing Gao, Bing Shen, Michael X Zhu

Open access · hybridAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Science China. Life sciences, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.0field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 8 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 2 countries.

Jie FuDepartment of Physiology, Anhui Medical University, Hefei, 230032, China.
ZhaoBing Gao
Bing Shen
Michael X Zhu
Anhui Medical University · CNShanghai Institute of Materia Medica · CNThe University of Texas Health Science Center at Houston · US

Funding

Molecular mechanism of regulation of mI(CAT) in intestinal smooth muscle cellsR01DK081654 · NIDDK · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI ZHU, MICHAEL X · 2009 to 2012
$1.2M
NIDDK NIH HHS DK081654NIDDK NIH HHS R01 DK081654
6 · The paper itself

Abstract

Canonical transient receptor potential 4 (TRPC4) forms non-selective cation channels that contribute to phospholipase C-dependent Ca(2+) entry into cells following stimulation of G protein coupled receptors and receptor tyrosine kinases. Moreover, the channels are regulated by pertussis toxin-sensitive Gi/o proteins, lipids, and various other signaling mechanisms. TRPC4-containing channels participate in the regulation of a variety of physiological functions, including excitability of both gastrointestinal smooth muscles and brain neurons. This review is to present recent advances in the understanding of physiology and development of small molecular modulators of TRPC4 channels.

Indexed as

AnimalsHumansTRPC Cation ChannelsTRPC4 ion channelTRPC Cation Channels

Identifiers

PMID25480324
PMCPMC4458143
OpenAlexW2071954389

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.