ArticleBMC genomics2014
Highly expressed captured genes and cross-kingdom domains present in Helitrons create novel diversity in Pleurotus ostreatus and other fungi.
Article in BMC genomics, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
16 citing papers in PubMed, 27 citations in OpenAlex.
- Helitrons are enriched in lichenized fungi with long generation lengths and small distribution sizes.G3 (Bethesda, Md.) · 2026Article
- Genome reshaping by Helitron transposons in Fusarium oxysporum TR4 affects secondary metabolism but not virulence.Nature communications · 2026Article
- The tiny germline chromosomes of Paramecium aurelia have an exceptionally high recombination rate and are capped by a new class of Helitrons.BMC biology · 2026Article
- Chromosome-Level Genome Announcement of the MonokaryoticJournal of fungi (Basel, Switzerland) · 2025Article
- Asymmetric mitonuclear interactions trigger transgressive inheritance and mitochondria-dependent heterosis in hybrids of the model systemIMA fungus · 2025Article
- Comparative genomics and transcriptomics reveal differences in effector complement and expression between races ofFrontiers in plant science · 2024Article
- Strain Degeneration inJournal of fungi (Basel, Switzerland) · 2021Article
- The Assembled and Annotated Genome of the Fairy-Ring Fungus Marasmius oreades.Genome biology and evolution · 2021Article
- Metabolic Potential, Ecology and Presence of Associated Bacteria Is Reflected in Genomic Diversity of Mucoromycotina.Frontiers in microbiology · 2021Article
- Giant Transposons in Eukaryotes: Is Bigger Better?Genome biology and evolution · 2019Review
- Somatic transposition and meiotically driven elimination of an active helitron family in Pleurotus ostreatus.DNA research : an international journal for rapid publication of reports on genes and genomes · 2017Article
- Using bioinformatic and phylogenetic approaches to classify transposable elements and understand their complex evolutionary histories.Mobile DNA · 2017Review
- Genomic and phylogenetic evidence of VIPER retrotransposon domestication in trypanosomatids.Memorias do Instituto Oswaldo Cruz · 2016Article
- Transposable Elements versus the Fungal Genome: Impact on Whole-Genome Architecture and Transcriptional Profiles.PLoS genetics · 2016Article
- Non-canonical Helitrons inMobile DNA · 2016Article
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Corrections and comments
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Authors and funding
10 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundHelitrons are class-II eukaryotic transposons that transpose via a rolling circle mechanism. Due to their ability to capture and mobilize gene fragments, they play an important role in the evolution of their host genomes. We have used a bioinformatics approach for the identification of helitrons in two Pleurotus ostreatus genomes using de novo detection and homology-based searching. We have analyzed the presence of helitron-captured genes as well as the expansion of helitron-specific helicases in fungi and performed a phylogenetic analysis of their conserved domains with other representative eukaryotic species.
resultsOur results show the presence of two helitron families in P. ostreatus that disrupt gene colinearity and cause a lack of synteny between their genomes. Both putative autonomous and non-autonomous helitrons were transcriptionally active, and some of them carried highly expressed captured genes of unknown origin and function. In addition, both families contained eukaryotic, bacterial and viral domains within the helitron's boundaries. A phylogenetic reconstruction of RepHel helicases using the Helitron-like and PIF1-like helicase conserved domains revealed a polyphyletic origin for eukaryotic helitrons.
conclusionP. ostreatus helitrons display features similar to other eukaryotic helitrons and do not tend to capture host genes or gene fragments. The occurrence of genes probably captured from other hosts inside the helitrons boundaries pose the hypothesis that an ancient horizontal transfer mechanism could have taken place. The viral domains found in some of these genes and the polyphyletic origin of RepHel helicases in the eukaryotic kingdom suggests that virus could have played a role in a putative lateral transfer of helitrons within the eukaryotic kingdom. The high similarity of some helitrons, along with the transcriptional activity of its RepHel helicases indicates that these elements are still active in the genome of P. ostreatus.
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