Trial reportExperimental brain research2015
Cognitive effects and autonomic responses to transcranial pulsed current stimulation.
Trial report in Experimental brain research, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06775145 (Therapeutic Effect of Neuromodulation on Anxiety Disorders by High-Definition Transcranial Electrical Stimulation), which is not on this map. Cited by 23 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Therapeutic Effect of Neuromodulation on Anxiety Disorders by High-Definition Transcranial Electrical Stimulation
Who cites it
23 citing papers in PubMed, 2 syntheses or guidelines pooled it, 48 citations in OpenAlex.
- Mapping the Causal Correlates of Risky and Ambiguous Decision-Making: Evidence from tES Research.Brain topography · 2025Pooled it
- Pooled it
- Effects of transcranial pulsed current stimulation on sleep quality in Student-Athletes with different types of sleep disorders.BMC psychiatry · 2026Trial
- Effects of laughter on focus and stress in middle-aged adults: a single-blind, randomized controlled trial.BMC complementary medicine and therapies · 2025Trial
- Patterns of brain oscillations across different electrode montages in transcranial pulsed current stimulation.Neuroreport · 2017Trial
- Neural signature of tDCS, tPCS and their combination: Comparing the effects on neural plasticity.Neuroscience letters · 2017Trial
- Tolerability of Repeated Application of Transcranial Electrical Stimulation with Limited Outputs to Healthy Subjects.Brain stimulationTrial
- Neuroprotective Effects of Transcranial Pulsed Current Stimulation: Modulation of Microglial Polarization in Traumatic Brain Injury.CNS neuroscience & therapeutics · 2025Article
- The effect of transcranial pulse current stimulation on the accumulation of exercise-induced fatigue in college students after moderate intensity exercise evidence from central and peripheral sources.Frontiers in physiology · 2025Article
- The distinct and potentially conflicting effects of tDCS and tRNS on brain connectivity, cortical inhibition, and visuospatial memory.Frontiers in human neuroscience · 2024Article
- Article
- Mechanisms of Action of Noninvasive Brain Stimulation with Weak Non-Constant Current Stimulation Approaches.Iranian journal of psychiatry · 2023Article
- Effect of Transcranial Pulsed Current Stimulation on Fatigue Delay after Medium-Intensity Training.International journal of environmental research and public health · 2022Article
- Transcranial Pulsed-Current Stimulation versus Transcranial Direct Current Stimulation in Patients with Disorders of Consciousness: A Pilot, Sham-Controlled Cross-Over Double-Blind Study.Brain sciences · 2022Article
- The effects of direct current stimulation and random noise stimulation on attention networks.Scientific reports · 2021Article
- Home-based transcranial direct current stimulation (tDCS) and motor imagery for phantom limb pain using statistical learning to predict treatment response: an open-label study protocol.Principles and practice of clinical research (2015) · 2021Article
- Hacking the Brain: Dimensions of Cognitive Enhancement.ACS chemical neuroscience · 2019Review
- Removal of Gross Artifacts of Transcranial Alternating Current Stimulation in Simultaneous EEG Monitoring.Sensors (Basel, Switzerland) · 2019Article
- Cortical Plasticity Induced by Anodal Transcranial Pulsed Current Stimulation Investigated by Combining Two-Photon Imaging and Electrophysiological Recording.Frontiers in cellular neuroscience · 2019Article
- Effect of Theta Transcranial Alternating Current Stimulation and Phase-Locked Transcranial Pulsed Current Stimulation on Learning and Cognitive Control.Frontiers in neuroscience · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 3 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Transcranial pulsed current stimulation (tPCS) is emerging as an option in the field of neuromodulation; however, little is known about its effects on cognition and behavior and its neurophysiological correlates as indexed by autonomic responses. Our aim was to identify the effects of tPCS on arithmetic processing and risk-taking behavior, and to further categorize physiological autonomic responses by heart rate variability (HRV) and electrodermal activity measurements before, during, and after exposure to task performance and stimulation. Thirty healthy volunteers were randomized to receive a single session of sham or active stimulation with a current intensity of 2 mA and a random frequency between 1 and 5 Hz. Our results showed that tPCS has a modest and specific effect on cognitive performance as indexed by the cognitive tasks chosen in this study. There was a modest effect of active tPCS only on performance facilitation on a complex-level mathematical task as compared to sham stimulation. On autonomic responses, we observed that HRV total power increased while LF/HF ratio decreased in the tPCS active group compared to sham. There were no group differences for adverse effects. Based on our results, we conclude that tPCS, in healthy subjects, has a modest and specific cognitive effect as shown by the facilitation of arithmetical processing on complex mathematical task. These effects are accompanied by modulation of the central autonomic network providing sympathetic-vagal balance during stressful conditions. Although behavioral results were modest, they contribute to the understanding of tPCS effects and cognitive enhancement.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.