ArticlePloS one2014
Inactivation of Fam20C in cells expressing type I collagen causes periodontal disease in mice.
Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 20 citations in OpenAlex.
- Periodontitis treatment and microbiome in a patient with FAM20A mutation: Case study of 1.5 years.Clinical advances in periodontics · 2026Article
- FAM20C: A key protein kinase in multiple diseases.Genes & diseases · 2025Review
- Ablation of FAM20C caused short root defects via suppressing the BMP signaling pathway in mice.Journal of orofacial orthopedics = Fortschritte der Kieferorthopadie : Organ/official journal Deutsche Gesellschaft fur Kieferorthopadie · 2023Article
- Non-lethal Raine Syndrome Report Lacking Characteristic Clinical Features.Journal of molecular neuroscience : MN · 2021Article
- Functions of Matricellular Proteins in Dental Tissues and Their Emerging Roles in Orofacial Tissue Development, Maintenance, and Disease.International journal of molecular sciences · 2021Review
- FAM20C directly binds to and phosphorylates Periostin.Scientific reports · 2020Article
- Constitutive activation of β-catenin in ameloblasts leads to incisor enamel hypomineralization.Journal of molecular histology · 2018Article
- FAM20C regulates osteoblast behaviors and intracellular signaling pathways in a cell-autonomous manner.Journal of cellular physiology · 2018Article
- FAM20C could be targeted by TET1 to promote odontoblastic differentiation potential of human dental pulp cells.Cell proliferation · 2018Article
- Abrogation of Fam20c altered cell behaviors and BMP signaling of immortalized dental mesenchymal cells.Experimental cell research · 2018Article
- Periodontal disease and FAM20A mutations.Journal of human genetics · 2017Article
- Specific ablation of mouse Fam20C in cells expressing type I collagen leads to skeletal defects and hypophosphatemia.Scientific reports · 2017Article
- Inactivation of bone morphogenetic protein 1 (Bmp1) and tolloid-like 1 (Tll1) in cells expressing type I collagen leads to dental and periodontal defects in mice.Journal of molecular histology · 2017Article
- Conditional Alpl Ablation Phenocopies Dental Defects of Hypophosphatasia.Journal of dental research · 2017Article
- Immortalized Mouse Floxed Fam20c Dental Papillar Mesenchymal and Osteoblast Cell Lines Retain Their Primary Characteristics.Journal of cellular physiology · 2015Article
- Phosphorylation and Alternative Splicing of 7B2 Reduce Prohormone Convertase 2 Activation.Molecular endocrinology (Baltimore, Md.) · 2015Article
- The ABCs of the atypical Fam20 secretory pathway kinases.The Journal of biological chemistryReview
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
Abstract
backgroundFAM20C is a kinase that phosphorylates secretory proteins. Previous studies have shown that FAM20C plays an essential role in the formation and mineralization of bone, dentin and enamel. The present study analyzed the loss-of-function effects of FAM20C on the health of mouse periodontal tissues.
methodsBy crossbreeding 2.3 kb Col 1a1-Cre mice with Fam20Cfl/fl mice, we created 2.3 kb Col 1a1-Cre;Fam20Cfl/fl (cKO) mice, in which Fam20C was inactivated in the cells that express Type I collagen. We analyzed the periodontal tissues in the cKO mice using X-ray radiography, histology, scanning electron microscopy and immunohistochemistry approaches.
resultsThe cKO mice underwent a remarkable loss of alveolar bone and cementum, along with inflammation of the periodontal ligament and formation of periodontal pockets. The osteocytes and lacuno-canalicular networks in the alveolar bone of the cKO mice showed dramatic abnormalities. The levels of bone sialoprotein, osteopontin, dentin matrix protein 1 and dentin sialoprotein were reduced in the Fam20C-deficient alveolar bone and/or cementum, while periostin and fibrillin-1 were decreased in the periodontal ligament of the cKO mice.
conclusionLoss of Fam20C function leads to periodontal disease in mice. The reduced levels of bone sialoprotein, osteopontin, dentin matrix protein 1, dentin sialoprotein, periostin and fibrillin-1 may contribute to the periodontal defects in the Fam20C-deficient mice.
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